Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Study on Selective Anti-cancer Effects by the Water-extracts of Selaginella Tamariscina in Cancer Cell lines

권백물추출물의 선별적인 항암작용에 대한 연구

  • Lee Sung Won (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Ahn Seong Hun (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Gwak Gun Sin (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Kwak Sup (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee Jang Cheon (Department of Oriental Medical Prescription Sangi University) ;
  • Mun Yean Ja (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Woo Won Hong (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 이성원 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 안성훈 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 곽근신 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 곽섭 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 이장천 (상지대학교 한의과대학 본초방제학교실) ;
  • 문연자 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 우원홍 (원광대학교 한의학전문대학원 한약자원개발학과)
  • Published : 2002.12.01
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Abstract

Selaginella Tamariscina is widely used in the traditional oriental herbal medicine for its anti-inflammatory, anti-cancer effects. The effects of aqueous extracts of Selaginella Tamariscina (ST) on the cell viability and induction of apoptotic cell death were investigated in A549, Raw 264.7, C6-glioma. Jurkat and HL-60 cells. The cell viability after treating with extract of Selaginella Tamariscina was quantified by MTT assay method. The results showed that ST decreased the cell viability in HL-60 and Jurkat cells not in A549, Raw 264.7 and C6-glioma cells. And we also observed the chromatin condensation and DNA fragmentation in HL-60 and Jurkat cells. The enzyme activity of caspase-3, tightly regulated by an apoptosis activating complex, were markedly increased in HL-60 cells treated with the ST by dose-dependent manner. In conclusion, our results suggest that the extract of Selaginella Tamariscina may induce the selective apoptotic cell death in HL-60 and Jurkat cells via activation of caspase-3.

Keywords

References

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