Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Study of Paljinhangahm-dan on Anti-tumoral Effect and Mechanism

팔진항암단의 항종양효과 및 기전연구

  • Bae Nam Kyu (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Moon Seok Jae (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Won Jin Hee (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Kim Dong Woung (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Moon Goo (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University)
  • 배남규 (원광대학교 한의과대학 배계내과학교실) ;
  • 문석재 (원광대학교 한의과대학 배계내과학교실) ;
  • 원진희 (원광대학교 한의과대학 배계내과학교실) ;
  • 김동웅 (원광대학교 한의과대학 배계내과학교실) ;
  • 문구 (원광대학교 한의과대학 배계내과학교실)
  • Published : 2002.12.01
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Abstract

Recent evidence suggests that many Oriental Medicinal prescriptions are effective in cancer patients as a supportive care. Oriental Medicinal herbs have been investigated extensively and are known to have multiple pharmacological effect. These herbs contain a variety of ingredients which may act synergistically to inhibit tumor cell division, to increase tumor cell death (apoptosis), and to increase the proportion of immune cells within tumor. Paljinhangahm-dan (Paljin) has been used to treat for cancer patients in Oriental Medicine for decades. The effects of aqueous extract of Paljin on the induction of apoptotic cell death were investigated in human leukemia cell lines (HL-60, Jurkat, Molt-4 and U937). The viability of leukemia cells was markedly decreased by Paljin in a dose-dependent manner. Paljin induced the apoptotic death of leukemia cells, which was characterized by the ladder-pattern DNA fragmentation, and chromatin condensation of the nuclei. Paljin digested Bid protein but did not affect Bcl-2 protein level and also, induced mitochondrial dysfunction disrupted as shown as the mitochondrial membrane potential. It activated caspase-9 and caspase-3. thereby resulted in cleavage of poly(ADP) ribose polymerase(PARP). These results indicate that Paljin induces apoptosis of human leukemia cells via activation of intrinsic caspase cascades with mitochondrial dysfunction.

Keywords

References

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