Advances in pediatric surgery
- Volume 8 Issue 2
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- Pages.101-106
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- 2002
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- 2635-8778(pISSN)
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- 2635-8786(eISSN)
Inhibition of Tumor Growth and Angiogenesis by KJ3, Betulinic Acid, and Fumagillin in Mouse Neuroblastoma
신생혈관 억제제 KJ3, Betulinic acid, Fumagillin의 혈관형성억제 및 신경모세포종에 대한 치료효과
- Choi, Seung-Hoon (Division of Pediatric Surgery, Brain Korea 21 Project for Medical Science Yonsei University College of Medicine) ;
- Lee, Jung-Hee (Division of Pediatric Surgery, Brain Korea 21 Project for Medical Science Yonsei University College of Medicine) ;
- Hwang, Eui-Ho (Division of Pediatric Surgery, Brain Korea 21 Project for Medical Science Yonsei University College of Medicine)
- Published : 2002.12.30
Abstract
The antiangiogenic effects of novel agent KJ3, Betulinic acid, and Fumagillin on the neovascularization were studied by examining ultrastructural alterations in the vasculature of synthetic gelform and mouse neuroblastoma C1300. Small pieces of gelform with 0.4% agar were introduced subcutaneously (s.c.) in 7 week old male CH3/HeJ mice. After the