Advances in pediatric surgery

Korean Association of Pediatric Surgeons (대한소아외과학회)
권호 표지

Comparative Nerve Distribution of the Pylorus in Infantile Hypertrophic Pyloric Stenosis

영아 비후성 유문협착증에서 유문부의 신경분포의 비교

  • Kim, Gang-Do (Department of Surgery, School of Medicine, Catholic University of Daegu) ;
  • Joo, Dae-Hyun (Department of Surgery, School of Medicine, Catholic University of Daegu) ;
  • Yoo, Yong-Oon (Department of Surgery, School of Medicine, Catholic University of Daegu) ;
  • Park, Sung-Hwan (Department of Surgery, School of Medicine, Catholic University of Daegu) ;
  • Park, Ki-Ho (Department of Surgery, School of Medicine, Catholic University of Daegu) ;
  • Park, Jae-Bok (Department of Pathology, School of Medicine, Catholic University of Daegu)
  • 김강도 (대구가톨릭대학교 의과대학 외과학교실) ;
  • 주대현 (대구가톨릭대학교 의과대학 외과학교실) ;
  • 유용운 (대구가톨릭대학교 의과대학 외과학교실) ;
  • 박성환 (대구가톨릭대학교 의과대학 외과학교실) ;
  • 박기호 (대구가톨릭대학교 의과대학 외과학교실) ;
  • 박재복 (대구가톨릭대학교 의과대학 병리학교실)
  • Published : 2002.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Infantile hypertrophic pyloric stenosis (IHPS) a common childhood disorders characterized by nonbilious projectile vomiting, an olive shaped mass in the right upper quadrant of the abdomen and visible gastric peristaltic wave in the upper abdomen. Its etiology and pathogenesis are not clear but abnormal nerve distribution of the pylorus has been $postulated^{2-6}$. We performed immunocytochemical staning to the pyloric muscle from 10 IHPS and 3 controls patients, utilizing specific monoclonal antibody to NCAM(neural cell adhesion molecule). In IHPS patients, the number of NCAM protein immunoreactive nerve fibers were less than that in normal subjects. Auerbach myenteric plexuse was well developed and interbundle nerve plexuse was present but nerve fibers supplying individual muscle cells in smooth muscle bundles were poorly developed. These results indicate reduction of innervation in smooth muscles in IHPS patients that possibly contributes to the pathogenesis of IHPS.

Keywords