Journal of Korean Physical Therapy Science (대한물리치료과학회지)
- Volume 9 Issue 1
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- Pages.89-94
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- 2002
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- 2733-6441(pISSN)
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- 2733-645X(eISSN)
Reduction of muscle cyclooxygenase-2 with transcutaneous electrical nerve stimulation and cold therapy in rats of carrageenan-induced inflammatory muscle pain
Carrageenan으로 유도된 염증성 근통증 흰쥐 모델에서 경피신경전기자극과 냉치료에 의한 비복근의 cyclooxygenase-2의 감소
- Paek, Yun-Woong (Department of Physical Therapy, Kwangju Health College) ;
- Chae, Yun-Won (Department of Physical Therapy, Kwangju Health College)
- Published : 2002.03.29
Abstract
Prostaglandins are generated through two isoforms of the enzyme cyclooxygenase, constitutively expressed cyclooxygenase(COX)-1 and COX-2, which is induced at sites of inflammation. Inhibition of COX-2 is desirable as this may avoid side effects seen with NSAIDs. We examined the effects of transcutaneous electrical nerve stimulation and cold therapy on the levels of muscle cycloooxygenase-2 mRNA in rats of carrageenan-induced inflammatory. The method of behavioral assessment were paw withdrawal latency(PWL) and tail flick test(TFT). The COX-2 mRNA levels were quantified by reverse transcription-polymerase chain reaction (RT-PCR). Following the transcutaneous electrical nerve stimulation and cold therapy, PWL and TFT were increased and COX-2 mRNA expression in gastrocnemius muscles were decreased. These results suggest that a transcutaneous electrical nerve stimulation and cold therapy were good therapy for a muscle pain.