대한한의학회지 (The Journal of Korean Medicine)

  • 제23권4호
  • /
  • Pages.169-185
  • /
  • 2002
  • /
  • 1010-0695(pISSN)
  • /
  • 2288-3339(eISSN)
대한한의학회 (The Society of Korean Medicine)
권호 표지

사삼맥문동탕이 Indomethacin으로 유발된 mouse의 대장 점막 손상에 미치는 영향

The Effects of Sasammaickmoondong-tang against Colonic Mucosal Lesions

  • 최준혁 (동국대학교 한의과대학 내과학 교실) ;
  • 임성우 (동국대학교 한의과대학 내과학 교실)
  • 발행 : 2002.12.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objectives: This study was carried out to investigate 1he effects of Sasammaickmoondong-tang(SME) on colonic mucosal lesions induced by indomethacin in mouse. Methods: The normal group is 1hat no inflammation elicitated mouse. Control group is that gastro-inflammation elicitated mouse. Sample group is that SME administered mouse after gastro-inflammation elicitation. Results: In the common morphology and histochemical change, control group was observed various injury-mucous surface cell, micro-villi, paneth cell, surface epithelial cell, goblet cell-by hemorrhagic erosion, while sample group was as same as normal group. In the immunohistochemical change, 1he distributions of COX-1, Bcl-2, and BrdU treated with SME noticeably increased than control group(P<0.05). The distributions of TUNEL, $NF-{\kappa}B$, COX-2, $IL-2R-\alpha$, NK-1.1, ICAM-1, and CD11b/18 treated with SME noticeably decreased than control group(P<0.05). And the distribution of SBA was as same as normal group. Conclusions: According to the above results, it is supposed that Sasammaickmoondong-tang is applicable to colonic mucosal lesions.

키워드

참고문헌

  1. 대한내과학회지 v.57 no.4 한국인의 염증성 장질환 송인성
  2. 헤리슨 내과학 해리슨 내과학 편찬위원회
  3. 1996 최신지견 내과학 Ⅰ 서울대학교 의과대학 내과학교실
  4. 한방성인병학회지 v.5 no.1 궤양성 대장염의 한의학적 접근방식에 관한 연구 강태희;원진희
  5. 中醫雜誌 v.37 no.1 健脾祛濕方藥對慢性潰瘍性直腸炎變態反應影響的對照觀察 齊錦生
  6. 北京中醫 v.4 中藥口服及灌腸治療慢性非特異性潰瘍性結腸炎124例 蘇路俠
  7. 天津中醫 v.15 no.5 中醫藥治療難治性潰瘍性結腸炎臨床觀察 苗靑
  8. 溫病條辨 吳鞠通
  9. 비계내과학 전국한의과대학 비계내과학교수(공저)
  10. 방약합편해설 신재용(편저)
  11. 중의내과학 張伯臾
  12. 대한한의학회지 v.18 no.1 大建中湯의 항궤양 및 위장관에 미치는 효과에 관한 실험적 연구 김혁규;백태현
  13. 대한한의학회지 v.19 no.1 加味香砂六君子湯의 Indomethacin 유도 위점막손상에 미치는 항산화효과 김경선;신흥묵
  14. 대한한방내과학회지 v.19 no.2 오패산이 HCL-aspirin으로 유발된 백서의 위궤양에 미치는 면역조직학적 연구 한상순;한상원;박순달
  15. 대한한방내과학회지 v.20 no.2 四君子湯合蒼朮地楡湯이 위점막손상에 미치는 영향 손정숙;임성우
  16. 대한한방내과학회지 v.20 no.2 향사육군자탕 및 향사육군자탕가미방이 흰쥐의 실험적 위궤양에 미치는 면역조직학적 연구 김종대
  17. 대한한방내과학회지 v.21 no.4 단삼음이 흰쥐의 소화성 궤양에 미치는 영향 전창민;민건우;박종혁;윤철호;정지천;강정준;신억섭;김형진
  18. 대한한방내과학회지 v.22 no.1 소건중탕가 용골모려가 흰쥐의 실험적 위궤양에 미치는 영향 김태중;이윤희;최우석;변준석;박순달
  19. 녹십자 의보 v.25 no.1 염증성 장질환의 분류 및 역학 송인성
  20. 녹십자 의보 v.25 no.1 염증성 장질환의 병리학적 특징 유은실
  21. 녹십자 의보 v.25 no.1 염증성 장질환의 원인과 발생기전 홍은경
  22. 본초학 전국한의과대학 본초학교실(공편)
  23. 대한한의학회지 v.23 no.3 도적지유탕이 궤양성 대장염 유발 흰쥐에 미치는 영향 김승욱;임성우
  24. 사삼맥문동탕이 위$\cdot$십이지장 점막 손상의 회복에 미치는 영향 김주성
  25. J. Clin. Gastroenterol v.27 Prostaglandins in the stomach. an update Arakawa T;Higuchi K;Fukuda T;Fujiwara Y;Kobayashi K;Kuroki T
  26. Am J med. v.105 Gastrointestinal side effects of nonsteroidal anti-inflammatory drug Cryer B;Kimmey MB
  27. Current Opinion in Rheumatology v.10 Biology and toxic effects of nonsteroidal anti-inflammatory drugs Siomon LS
  28. Prostaglandins & other Lipid Mediators v.56 The advent of highly selective inhibitors of cyclooxygenase-a review Cryer B;Dubois A
  29. J Gastroenterol v.33 Roles of COX-1 and COX-2 in gastrointestinal pathophysiology Sakamoto C
  30. J Clin Epidem v.53 Measuring cell proliferation in rectal mucosa : Comparing bromodeoxyuridine(BrdU) and proliferating cell nuclear antigen(PCNA) assays Kulldorff M;McShane LM;Schatzkin A;Freedman LS;Wargovich MJ;Woods C;Purewal M;Burt RW;Lawson M;Mateski DJ;Lanza E;Corle DK;O'Brien B;Moler J
  31. Europe J Pharmaco v.342 Activation of gene growth facters and cyclooxygenases in rat gastric mucosa during recovery form stress damage Konturek PC;Brozowski T;Konturek SJ;Taut A;Sliwowski Z;Stachura J;Hahn EG
  32. Europe J Pharmaco v.397 Non-steroidal anti-inflammatory drugs and apoptosis in the gastrointestinal tract : potential role of the pentose phosphate pathways Porter SN;Howarth GS;Butler RN
  33. Int J colorectal Dis v.16 Prolonged activation of mitogen-activated protein kinases during NSAID-induced apoptosis in HT-29 colon cancer cells Kim TI;Jin SH;Kim WH;Kang EH;Choi KY;Kim HJ;Shin SK;Kang JK
  34. J. Exp. Med. v.178 The siginificance of low Bcl-2 expression by CD45RO+ T cell in normal individuals and patients with acute viral infections : The role of apoptosis in T cell memory Akbar AN;Borthick N;Salmon M;Gombert W;Bofill M;Shamsadeen N;Pilling D;Pett S;Grundy JE;Janossy G
  35. Vetrinary Immuno immunopath v.72 Lymphocyte migration in the intestinal mucosa : entry, transit and emigration of lymphoid cells and the influence of antigen Rothktter HJ;Pabst R;Bailey M
  36. Inflamm res. v.47 Interleukin-15 and its role in chronic inflammatory diseases Kirman I;Vainer B;Nielsen OH
  37. Transplant Proceed v.32 Upregulated intragraft gene expression, ICAM-1 and IL-2R molecules, and apoptotic epithelial cells during regection of rat SAMll intestine allgrafts Li YX;Li N;Li YS;Wu B;Li JS
  38. Abodm Imaging v.23 NSAID injury to the SAMll intestine Zalev AH;Gardiner GW;Warren RE
  39. J. Clin Gastroenterol v.12 Alternation of gastric mucosal glycoprotein in gastric mucosa in stress : A light and electron microscopic study Kitajima M;Mogi M;Kiuchi T;Shimizu A;Nakajima M;Oshima A;Kawakami H;i Hirano H
  40. v.266 Lectins are sensitive tools for defining the differentiation programs of mouse gut epithelial cell lineages Falk P;Roth KA;Gordon JI