The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
권호 표지

The Protective Effect of Uncariae Ramulus Et Uncus Extract on Middle Cerebral Artery Occlusion(MACO)

조구등이 뇌허혈을 유발시킨 백서에서의 뇌신경보호효과

  • 강상렬 (경산대학교 한의과대학 심계내과학교실) ;
  • 강승준 (경산대학교 한의과대학 심계내과학교실) ;
  • 금현수 (경산대학교 한의과대학 심계내과학교실) ;
  • 전연이 (경산대학교 한의과대학 심계내과학교실) ;
  • 이은주 (경산대학교 한의과대학 심계내과학교실) ;
  • 박치상 (경산대학교 한의과대학 심계내과학교실) ;
  • 박창국 (경산대학교 한의과대학 심계내과학교실) ;
  • 허진화 (경산대학교 한의과대학 생리학교실) ;
  • 양재하 (경산대학교 한의과대학 생리학교실)
  • Published : 2002.03.01
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives: Uncariae Ramulus Et Uncus extract is clinically used in Korea to treat ischemic cerebral damage. The present study was undertaken to study the neuroprotective effect of Uncariae Ramulus Et Uncus extract in middle cerebral artery occlusion (MCAO) rats. Methods: Changes of extracellular levels of dopamine, DOPAC, HVA. and HIAA in striatum were collected at 20 minutes interval by in vivo microdialysis and then analyzed by HPLC (high performance liquid chromatography) in rats subjected to permanent focal cerebral ischemia induced by 2 hours of MCAO. Uncariae Ramulus Et Uncus extract was orally administrated before MCAO. Different animals were used for measurement of cerebral infarction volume induced by 24 hours of MCAO with TIC staining and image analysis. Results: Extracellular levels of dopamine decreased after treatment with Uncariae Ramulus Et Uncus extract, while extracellular levels of DOPAC and HVA significantly increased. Cerebral infarction volume also significantly decreased after treatment with Uncariae Ramulus Et Uncus extract. Conclusions: These results provided evidence that Uncariae Ramulus Et Uncus extract can produce a neuroprotective effect on cerebral ischemia by regulating extracellular excitatory neurotransmitters.

Keywords

References

  1. 東垣十種醫書 李고
  2. 編註醫學入門 李천
  3. 國譯中風각詮 張壽신;文錫哉;元秦喜
  4. 대한내과학회지 v.43 no.5 우리나라 뇌졸중의 최근 10년간 변화양상에 대한 연구 송일환
  5. Am Heart J. v.83 no.6 The prognosis of untreated and treated hypertension and advantage of early treatment Smirk, F.H.
  6. HARRISON'S 내과학 Isselbacher, Kurt J.
  7. 藥物療法 v.2 醫學敎育硏修院
  8. FASEB J. v.4 Role of oxygen free radicals in carcinogenesis and brain ischemia Floyd, R.A.
  9. Journal of Cerebral Blood Flow and Metabolism v.9 Dynamics of extracellular Metabolites in the striatum after middle cerebral artery occlusion in rat monitored by intracerabral microdialysis Hilliered, L.;Hallstrn, A.;Sigersvrd, S.;Persson, L.;Ungerstedt, U.
  10. 申氏本草學 申佶求
  11. 臨床本草學 辛民敎
  12. 韓藥의 藥理, 成分, 臨床應用 v.1 陸昌洙;金成萬;鄭津牟;鄭明淑;金定禾;金勝培
  13. 韓藥臨床應用 v.1 李尙仁;安德均;辛民敎;盧昇鉉;李暎鍾;金先熙
  14. 本草綱目 v.4 李時珍
  15. 增補本草備要 v.3 汪庵
  16. 東醫病理學會誌 v.5 龍膽瀉肝湯 및 釣鉤藤, 夏枯草,車前子 加味方이 高血壓에 미치는 影響 金義泰;崔昇勳;安圭錫;文濬典
  17. 생약학회지 v.29 no.3 조구등 성분의 항경련 효과 김동영;최종원
  18. 釣鉤藤 水鍼이 鎭痛, 抗痙攣 및 鎭靜作用에 미치는 影響 申明燮
  19. 東醫病理學會誌 v.5 釣鉤藤 煎湯液이 家兎의 前庭眠球反射에 미치는 影響 文大煥
  20. The rat brain in sterotaxic coordinates Paxinos, G.;Watson, C.
  21. J Cereb Blood Flow Metab. v.9 Dynamics of extracellular metabolites in the striatum after middle cerebral artery occlusion in the rat monitored by intracerebral microdialysis Hillered, L.;Hallstrom, A.;Segersvard, S.;Persson, L.;Ungerstedt, U.
  22. J. Cereb. Blood flow Metab. v.15 In vivo models of cerebral ischemia: Effects of parenterally administered NMDA receptor glycine site antogonists Warner, D.S.;Martin, H.;Ludwig, P.;McAllister, A.;Keana, J.F.W.;Weber, E.
  23. Acta. Phys. Scand v.128 Microdialysis in the study of extracellular levels of amino acids in the rat brain Tossman, U.;Ungerstedt, U.
  24. J Neurochem. v.49 Extracelluar adnosine, inosine, hypoxanthine, and xanthine in relation to tissue nucleotides and purines in rat striatum during transient ischemia Hagberg, H.;Andersson, P.;Lacarewicz, J.;Jacobson, I.;Butcher, S.;Sandberg, M.
  25. Stroke v.20 Correlation between cerebral blood flow and histologic changes in a new rat model of middle cerebral artery occlusion Nagasawa, H.;Kogure, K.
  26. Bioststisstics v.3 A foundation for analysis in the health science Dinal, W.W.
  27. 心系內科學 v.1 全國韓醫科大學心系內科學敎室
  28. 河間三六書 劉完素
  29. 丹溪心法附餘 朱震亨
  30. 臨證指南醫案 葉天士
  31. 醫林改錯 王淸任
  32. 解剖藥理學 金鍾大;李漢基
  33. 신경전달물질 서유헌
  34. Kainic acid as a tool in neurobiology Neurotoxicity of excitatory amino acids Olney, J.W.;McGeer, E.G.(ed.);Olney, J.W.(ed.);McGeer, P.L.(ed.)
  35. J Neurochem v.51 Rapid postmortem increase in extracellular dopamine in the rat brain as assessed by brain microdialysis Vulto, A.G.;Sharp, T.;Ungerstedt, U.;Versteeg, D.H.G.
  36. J Cereb Blood Folw Metab. v.13 Elevation of neuroactive substances in the cortex of cats during prolonged focal ischemia Matsumoto, K.;Graf, R.;Rosner, G.;Taguchi, J.;Heiss, W.D.
  37. Neuropharmacology v.25 Amine mediated toxicity: the effects of dopamine, norepinephrine, 5-hydroxytryptamine, 6-hydroxydopanime, ascorbate, glutathione and peroxide on the in vitro activities of creatine and adenylate kinases in the brain of the rat Maker, H.S.;Weiss, C.;Brannan, T.S.
  38. Neurosci Lett. v.136 Serotonin may have neurotoxic properties Joseph, R.;Tsering, C.;Grunfeld, S.;Welch, K.M.A.
  39. Exp Brain Res. v.86 Changes in striatal dopamine neurochemistry and biochemistry after incomplete transient cerebral ischemia in the rat Nemeth, G.;Cintra, A.;Herb, J.M.(et al.)
  40. J Neurochem. v.54 Effects of transient forebrain ischemia and pargyline on extracellular concentrations of dopamine, serotonin, and their metabolites in the rat striatum as determined by in vivo microdialysis Damsma, G.;Biosvert, D.P.;Mudrick, L.A.;Wenksterm, D.;Fibiger, H.C.