Journal of Photoscience
- Volume 9 Issue 2
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- Pages.225-228
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- 2002
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- 1225-8555(pISSN)
Anti-apoptotic effect by Bcl-2 in UVB-irradiated keratinocytes.
- Takahashi, Hidetoshi (Departments of Dermatology, Asahikawa Medical College) ;
- Honma, Masaru (Departments of Dermatology, Asahikawa Medical College) ;
- Ishida-Yamamoto, Akemi (Departments of Dermatology, Asahikawa Medical College) ;
- Namikawa, Kazuhiko (Departments of anatomy Asahikawa Medical College) ;
- Miwa, Akiko (Department of Neurobiology, Tokyo Metroporitan Institute for Neuroscience) ;
- Okado, Haruo (Department of Neurobiology, Tokyo Metroporitan Institute for Neuroscience) ;
- Kiyama, Hiroshi (Departments of anatomy Asahikawa Medical College) ;
- Iizuka, Hajime (Departments of Dermatology, Asahikawa Medical College)
- Published : 2002.08.01
Abstract
Bcl-2 is a member of large bcl-2 family and protects cells from apoptosis. Using bcl-2-expressing adenovirus vector (Ad-bc1-2), we investigated the effect of bc1-2 on UVB-induced apoptosis. Adenovirus vector efficiently introduced bc1-2 gene in cultured normal mouse keratinocytes (NMK cells); almost all NMK cells (lx10