Journal of Photoscience
- Volume 9 Issue 2
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- Pages.201-204
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- 2002
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- 1225-8555(pISSN)
Regulation of Proopiomelanocortin and Melanocortin 1 Receptor by UVB: Inhibitory Effect of Antioxidants
- Funasaka, Yoko (Division of Dermatology, Department of Clinical Molecular Medicine, Faculty of Medicine, Kobe University Graduate School of Medicine)
- Published : 2002.08.01
Abstract
Epidermal cells produce a panel of antioxidants as well as cytokines after UVB irradiation, which counteract reactive oxygen species, however, how these antioxidants might regulate melanogenesis is unclear. An important constituent of the cellular antioxidant buffering system which controls the redox state of proteins is thioredoxin (TRX), a 13-kD protein that catalyzes thiol-disulfide exchange reactions, regulates activation of transcription factors, and possesses several other biological functions similar to cytokines. TRX suppressed the UVB-induced production and secretion of