Journal of Photoscience
- Volume 9 Issue 2
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- Pages.174-177
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- 2002
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- 1225-8555(pISSN)
Development of Novel Sugar Linked Photosensitizers for Photodynamic Therapy
- Yano, Shigenobu (Division of Material Science, Graduate School of Human Culture, Nara Women's University)
- Published : 2002.08.01
Abstract
Sugar-linked porphyrin and chlorin compounds have been synthesized. Phototoxicity of these compounds against the HeLa cell line was also examined. For the porphyrin derivatives, the higher activity was observed for a derivative having four OH-protected sugar moieties. For the chlorin derivatives, OH-unprotected free-base derivatives were generally effective. Singlet oxygen producing ability were examined to evaluate the activity on photodynamic therapy of the compounds.