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The Pharmaceutical Society of Korea (대한약학회)
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Which Dosing Scheme is Suitable for the Taxanes\ulcorner An in Vitro Model

  • Sanli, Ulus-Ali (Ege University Medical School, Department of Medical Oncology) ;
  • Uslu, Ruchan (Ege University Medical School, Department of Medical Oncology) ;
  • Karabulut, Bulent (Ege University Medical School, Department of Medical Oncology) ;
  • Sezgin, Canfeza (Ege University Medical School, Department of Medical Oncology) ;
  • Saydam, Guray (Ege University Medical School, Department of Hematology) ;
  • Omay, Serdar-Bedii (Ege University Medical School, Department of Hematology) ;
  • Goker, Erdem (Ege University Medical School, Department of Medical Oncology)
  • Published : 2002.08.01
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Abstract

The discovery and development of the taxane class of antitumor compounds represent significant advances in the treatment of patients with a variety of malignancies. These drugs are effectively used in the treatment of breast cancer. In this study we evaluated the efficacy of fractionated usage of both paclitaxel and docetaxel as a single agent in the breast cancer cell line MCF-7. It has been shown that the cytotoxic effect of paclitaxel was increased when the divided $IC_{50}$ concentrations were used sequentially and in contrast to paclitaxel, cytotoxic effect of docetaxel was decreased with the same schema and the single dose of $IC_{50}$ concentration was optimal. The cause of the difference between the cytotoxic effects of two agents with this schedule is obscure. Demonstrating mechanisms, which are responsible for these differences, will be important for more rational use of taxoids and to provide basis for the following clinical trials.

Keywords

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