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The Pharmaceutical Society of Korea (대한약학회)
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Three New Dammarane Glycosides from Heat Processed Ginseng

  • Park, Il-Ho (Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University) ;
  • Kim, Na-Young (Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University) ;
  • Han, Sang-Beom (Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University) ;
  • Kim, Jong-Moon (Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University) ;
  • Kwon, Sung-Won (Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University) ;
  • Kim, Hyun-Jung (Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University) ;
  • Park, Man-Ki (Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University) ;
  • Park, Jeong-Hill (Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University)
  • Published : 2002.08.01
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Abstract

Three new dammarane glycosides were isolated from the processed ginseng (SG; Sun Ginseng). Their structure were determined to be $3{\beta},{\;}12{\beta}-dihydroxydammar-20(21),24-diene-3-O-{\beta}-D-glucopyranosyl(1{\;}{\rightarrow}{\;}2)-{\beta}-D-glucopyranoside;{\;}3{\beta},{\;}12{\beta}-dihydroxydammar-20(21),24-diene-3-O-{\beta}-D-{\;}glucopyranoside{\;}and{\;}3{\beta},6{\alpha},12{\beta}-trihydroxydammar-20(21),24-diene-6-O-{\beta}-D-glucopyranoside$ based on spectroscopic evidences. The compounds were named as ginsenoside $Rk_1,{\;}Rk_2,{\;}and{\;}Rk_3$ respectively.

Keywords

References

  1. Baek, N. I., Kim, D. S., Lee, Y. H., Park, J. D., Lee, C. B., and Kim, S. I., Ginsenoside $Rh_4$, A Genuine Dammarane Glycoside from Korean Red Ginseng. Planta Med., 62, 86-87 (1996) https://doi.org/10.1055/s-2006-957816
  2. Han, D.S., Pharmacognogy, Dong Myoung Sa, Seoul, 1988
  3. Keum, Y. S., Park, K. K., Lee, J. M., Chun, K. S., Park, J. H., Lee, S. K., Kwon, H. J., and Surh, Y. J., Antioxidant and antitumor promoting activities of the methanol extract of heat-processed ginseng. Cancer Letters, 150, 41-48 (2000) https://doi.org/10.1016/S0304-3835(99)00369-9
  4. Kim, D. S., Baek, N. I., Park, J. D., Lee, Y. H., Jeong, S. Y., Lee, C. B., and Kim, S. I., Preparation and Structure Detemination of a New Glycoside, (20E)-Ginsenoside $Rh_3$, and its isomer from Diol-type Ginseng Saponins. Yakhak Hoeji, 39, 85-93 (1995)
  5. Kim, S. I., Baek, N. I., Kim, D. S., Lee, Y. H., Kang, K. S., and Park J. D., Preparation of a 20(S)-Ginsenoside $Rh_2$ and the 20(S) Epimer from Protopanaxadiol Saponins of Panax ginseng C.A. Meyer. Yakhak Hoeji, 35, 432-437 (1991)
  6. Kim, S. I., Kim, D. S., Lee, Y. H., Park, J. D., and Baek, N. I., Isolation of A Novel Dammarane-Glycoside, Ginsenoside $Rh_4$, from Korean Red Ginseng. Proceedings of 95 Korean-Japan Ginseng Symposium, 107 (1995)
  7. Kim, S. I., Park, J. D., Lee, Y. H., Nam, G. Y., and Baek , N. I., Preparation of 20(R)- and 20(S)-Ginsenoside $Rh_1$ from Ginsenoside Re. Korean J. Ginseng Sci., 15, 188-191 (1991)
  8. Kim, S. I., Park, J. H., Ryu, J. H., Park, J. D., Lee, Y. H., Park, J. H., Kim, T. H., Kim, J. M., and Baek, N. I., Ginsenoside $Rg_5$, A Genuine Dammarane Glycoside from Korean Red Ginseng. Arch. Pharm. Res., 19(5), 551-553 (1996) https://doi.org/10.1007/BF02986026
  9. Kim, W. Y., Kim, J. M., Han, S. B., Lee, S. K., Kim, N. D., Park, M. K., Kim, C. K., Park, J. H., Steaming of Ginseng at HighTemperature Enhances Biological Activity. J. Nat. Prod., 63, 1702-1704 (2000) https://doi.org/10.1021/np990152b
  10. Kitagawa, I., Yoshikawa, M., Yoshigara, M., Hayashi, T. and Taniyama, T., Chemical Studies on Crude Drug Precession. I. On the Constitution of Ginseng Radix Rubra (1). Yakugaku Zasshi, 103, 612-622 (1983) https://doi.org/10.1248/yakushi1947.103.6_612
  11. Ryu, J. H., Park, J. H., Eun, J. H., Jung, J. H., and Sohn, D. H., A dammarane glycoside from Korean red ginseng. Phytochemistry, 44, 931-933 (1997) https://doi.org/10.1016/S0031-9422(96)00661-9
  12. Sanada, S., Kondo, N., Shoji, J., Tanaka, O., and Shibata, S., Studies on the saponins of Ginseng. I. Structure of Ginsenoside-Ro, $-Rb_1$, $-Rb_2$, -Rc and Rd. Chem.Pharm. Bull., 22(2), 421-428 (1974a) https://doi.org/10.1248/cpb.22.421
  13. Sanada, S., Kondo, N., Shoji, J., Tanaka, O., and Shibata, S., Studies on the saponins of Ginseng. II. Structure of Ginsenoside-Re, -Rf, and $Rg_2$. Chem. Pharm. Bull., 22(10), 2407-2412 (1974b) https://doi.org/10.1248/cpb.22.2407