약학회지 (YAKHAK HOEJI)

  • 제46권5호
  • /
  • Pages.295-300
  • /
  • 2002
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  • 0377-9556(pISSN)
  • /
  • 2383-9457(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

루판 유도체의 합성 및 세포독성-I

Lupane Derivatives-I: Synthesis and Cytotoxic Activity

  • 유영제 (충남대학교 약학대학) ;
  • 김용 (충남대학교 약학대학) ;
  • 안병준 (충남대학교 약학대학)
  • You, Young-Jae (College of Pharmacy, Chungnam National University) ;
  • Kim, Yong (College of Pharmacy, Chungnam National University) ;
  • Ahn, Byung-Zun (College of Pharmacy, Chungnam National University)
  • 발행 : 2002.10.01
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초록

To observe the structure-activity relationship of lupane derivatives both on cytotoxic and antiangiogenic activity, twelve lupane derivatives were prepared; their antiangiogenic and cytotoxic activities were evaluated. Among them, four compounds were more cytotoxic than betulinic acid. Carboxylic acid at C28 seemed to be essential for cytotoxic activity. But, a selective cytotoxicity toward SK-MEL-2 was not observed. As for antiangiogenic activity, none of the compounds except lupeol showed antiangiogenic activity at 30 $\mu\textrm{g}$/mL.

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참고문헌

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