YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Vanadate-induced Platelet Aggregation and Inhibition Effect of Vanadium Yeast

Vanadate의 혈소판 응집작용과 Vanadium Yeast의 억제효과

  • Published : 2002.12.01
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Abstract

It has been well known that vanadium shows various physiological and pharmacological properties such as an insulin-mimetic effect. In view of the reported toxic effects there is the problems that the safety margin is narrow because of its strong toxicity, Vanadate was tested for its ability to cause blood aggregation. Although vanadate or $H_2O$$_2$ alone had little effect on platelet aggregation, treatment of vanadate and $H_2O$$_2$ together induced platelet aggregation indicated that it was occurred by pervandate or hydroxyl radical produced from the reaction of vanadate and $H_2O$$_2$. It was dependent on extracellular $Ca^{2+}$ion. Platelet aggregation caused by vanadate and $H_2O$$_2$ was inhibited by ascorbic acid, tocopherol, catalase, mannitol, and Tiron. In contrast to vanadate, vanadium yeast prepared by uptaking vanadate in yeast cells did not induce platelet aggregation in the presence of $H_2O$$_2$.>.

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References

  1. Heyliger, E. C., Tahiliani, G. A. and McNeill, J. H. : Effect of vanadate on elevated blood glucose and depressed cardiac performance of diabetic rats. Science. 227, 1474 (1985) https://doi.org/10.1126/science.3156405
  2. Roshchin, A. V., Ordzhonikidze, E. K. and Shalganova, I. V. : Vanadium-toxicity, metabolism, carrier state. J. Hyg. Epidemiol. Microbiol. Immunol. 24(4), 377 (1980)
  3. Hopkins, L. L. and Tilton, B. E. : Vanadium as an essential nutrient. Fed. Proc. 33(6), 1173 (1966)
  4. Toney, J. H., Murthy, M. S. and Marks, T. J. : Biodistribution and pharmacokinetics of vanadium following intraperitoneal administration of vanadocene dichloride to mice. Chem. Biol. Interact. 66(1), 45 (1985)
  5. Canalis, E. : Effect of sodium vanadate on deoxyribonucleic acid and protein synthesis in cultured rat calvariae. Endocrinology. 116(3), 855 (1985)
  6. Hamada, J. : Vanadium induced hemolysis of vitamin E deficient erythrocytes in Hepes buffer. Experientia. 50(1), 49 (1994) https://doi.org/10.1007/BF01992049
  7. Adler, A. J., Caruso, C. and Berlyne, G. M. : The effect of aluminum on the vanadium-mediated oxidation of NADH. Nephron. 69(1), 34 (1995)
  8. Zaporowska, H. and Wasilewski, W. : Haematological effects of vanadium on living organisms. Comp. Biochem. Physiol. C. 102(2), 223 (1992)
  9. Inazu, T., Taniguchi, T., Yanagi, S. and Yamamura, H. : Proteintyrosine phosphorylation of intact human platelets by vanadate with $H_{2}O_{2}$. Biochem. Biophys. Res. Commun. 170, 259 (1990) https://doi.org/10.1016/0006-291X(90)91268-W
  10. Young-Hyun Park : Effect of marine toxins on the rabbit platelets. J. Fd. Hyg. Safety. 10(2), 73 (1995)
  11. Bode, H. P., Friebel, C. and Fuhrmann, G. F. : Vanadium uptake by yeast cells. Biochimical et Biophysica Acta. 1022, 163 (1990) https://doi.org/10.1016/0005-2736(90)90110-A