YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Synthesis and Antiinflammatory-analgesic Activity of Monovalent and Bivalent Aminoantipyrines

Monovalent와 bivalent aminoantipyrine 유도체의 합성과 항염 진통활성

  • 김승재 (중앙대학교 약학대학 의약품화학교실) ;
  • 권오혁 (중앙대학교 약학대학 의약품화학교실) ;
  • 전상철 (중앙대학교 약학대학 의약품화학교실) ;
  • 박상민 (중앙대학교 약학대학 의약품화학교실) ;
  • 임채욱 (중앙대학교 약학대학 의약품화학교실) ;
  • 임철부 (중앙대학교 약학대학 의약품화학교실)
  • Published : 2002.06.01
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Abstract

Six novel 4-aminoantipyrine derivatives as potential nonsteroidal antiinflammatory and analgesic compounds were prepared and their antiinflammatory-analgesic activity were compared with antiprine. Succinyl chloride and Ac $_2$O were reacted with glycine, respectively, to give glycine compounds (3-4, 9-10), which were treated with hydroxysuccinimide and dicyclohexyl carbodiimide to yield active esters (5-6, 11-12), and then reacted with 4-aminoantipyrine to prepare 4-aminoantipyrine derivatives (7-8, 13-14). 4-Aminoantipyrine reacted with succinyl chloride and Ac $_2$O, respectively, to give succinyl bis aminoantipyrine (15) and acetyl aminoantipyrine (16). Compounds (7), (8) and (13) gave comparable antiinflammatory activity to antipyrine.

Keywords

References

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