한국환경성돌연변이발암원학회지 (Environmental Mutagens and Carcinogens)
- 제22권4호
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- Pages.259-265
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- 2002
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- 1225-6307(pISSN)
Endocrine Disrupting Activity of Seven Phthalate Analogues in vitro
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Ryu, Jae-Chun
(Toxicology Laboratory, Korea Institute of Science and Technology) ;
- Kim, Hyung-Tae (Toxicology Laboratory, Korea Institute of Science and Technology) ;
- Kim, Youn-Jung (Toxicology Laboratory, Korea Institute of Science and Technology) ;
- Jeon, Hee-Kyung (Toxicology Laboratory, Korea Institute of Science and Technology)
- 발행 : 2002.12.01
초록
Phthalate analogues are a plasticizer and solvent used in industry. Phthalates were reported to be a potential carcinogen classified in the category of suspected endocrine disruptors. Most common human exposure to these compounds may occur with contaminated food. They may migrate into food from plastic wrap or may enter food from general environmental contamination. Since these substances are not limited to the original products, and enter the environment, they have become widespread environmental pollutants, thus leading to a variety of phthalates that possibly threaten the public health. Concern about their use has been mounting. To screen and elucidate the endocrine disrupting activity and their mechanism of phthalate analogues, first of all, E-screen assay was performed in MCF7 human breast cancer cells with seven phthalate analogues. In this cell proliferation assay, only dibutyl phthalate (DBP) showed weak estrogenic activity. Also the yeast-based transcription assay to assess the interactions of DBP with the estrogen, androgen, and progesterone receptors was conducted. DBP in the concentration ranges from 10
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