Toxicological Research

  • 제18권3호
  • /
  • Pages.233-240
  • /
  • 2002
  • /
  • 1976-8257(pISSN)
  • /
  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
권호 표지

Haplotype Distribution of the β2-Adrenergic Receptor Gene in Korean Essential Hypertensives

  • Bae, Joon-Seol (Seoulin Bioscience Institute, Seoulin Bioscience, Co. Ltd.) ;
  • Kang, Byung-Yong (Department of Life Science, Samhyook University) ;
  • Lee, Kang-Oh (Department of Life Science, Samhyook University) ;
  • Yoon, Tae-Joong (Seoulin Bioscience Institute, Seoulin Bioscience, Co. Ltd.) ;
  • Kim, Jae-Hyoun (Department of Health Science, College of National Science, Dongduk Women University) ;
  • Kim, Ki-Tae (Seoulin Bioscience Institute, Seoulin Bioscience, Co. Ltd.)
  • 발행 : 2002.09.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

In view of the effect of $\beta_2$-Adrenergic receptors ($\beta_2$-AR) as a risk factor for essential hypertension, we investigated the Fnu4HI and MnlI RFLPs of $\beta_2$ -AR gene in the Korean patients with essential hypertension and normal controls. There were no significant differences in the allele and genotype of these polymorphisms between normotensive and essential hypertensive subjects. In ethnic comparison, the allele frequencies of these three sites contained Nde I RFLP reported the association with essential hypertension in Korean population previously, were very different from those of other ethnic populations studied. The significant linkage disequilibrium was detected only in hypertensive group between Nde I and Fnu4HI sites. The Fnu4HI RFLP was also significantly associated with plasma triglyceride (TG) level. Therefore, our results suggest that the significant association between Fnu4HI variation in the human $\beta_2$-AR gene and plasma TG level may reflect the potential role of human $\beta_2$-AR gene as one of the genetic components for cardiovascular risk.

키워드

참고문헌

  1. Hypertension v.25 Hypertension and the pathogenesis of atherosclerosis: oxidative stress and mediation of arterial inflammatory response: a new perspective Alexander,R https://doi.org/10.1161/01.HYP.25.2.155
  2. Environmental Mutagens Carcinogens v.21-1 Association between Arg16Gly mutation in the b₂-adrenergic receptor gene and hypertension in the Korean population Bae,J.S.;Kang,B.Y.;Kim,K.T.;Shin,J.H.;Lee,C.C.
  3. Am. J. Hum. Genet. v.32 Construction of a genetic linkage map using restriction fragment length polymorphisms Bostein,D.;White,R.L.;Skolnick,M.;Davis,R.W.
  4. J. Hypertents v.18 Association analysis of β2 adrenoceptor polymorpjisms with hypertension in a Black Afirican population Candy,G.;Samani,N.;Norton,G.;Woodiwiss,A.;Radevski,I.;Wheatley,A.;Cockcroft,J.;Hall,I.P. https://doi.org/10.1097/00004872-200018020-00006
  5. Arch. Intern. Med. v.157 Exacerbation of atherosclerosis by hypertension: potential mechamisms and clinical implications Chobanian,A.;Alexander,R. https://doi.org/10.1001/archinte.157.21.2413
  6. Circulation v.96 Association of β2 adrenoceptor polymorphisms with vascular reacticvity in humans Cockcroft,J.R.;Gazis,A.G.;White,D.J.;Wheatly,A.P.;Hall,I.P.
  7. Diabetes v.47 Gln27Glu variants of human β₂-adrenoreceptor gene is not associated with early-onset obesity in Danish men Echwald,S.M.;Srensen,T.I.A.;Tybjaerg-Hansen,A.;Andeesen,T.;Pedersen,O. https://doi.org/10.2337/diabetes.47.10.1657
  8. Clin. Chem. v.18 Estimation of the concentration of low-density lipoprotein cholesterol in plasma without the use of the preparative ultracentrifuge Friedwald,W.T.;Levy,R.I.;Fridrickson,D.S.
  9. Hypertension v.33 β2-adrenergic receptor variants affect resting blood pressure and agonist induced vasodilation in young adult Caucasians Gratze,G.;Fortin,J.;Labugger,R.;Binder,A.;Kotanko,P.;Timmermann,B. https://doi.org/10.1161/01.HYP.33.6.1425
  10. Lancet v.345 Association of Glu27 β2-adrenoceptor polymorphisms with lower airway reactivity in asthmatic subjects Hall,I.P.;Wheatley,A.;Wilding,P.;Liggett,S.B. https://doi.org/10.1016/S0140-6736(95)91994-5
  11. Journal of Internal Medicine v.245 The different effects of a Gln27Glu β2-adrenoceptor gene polymorphism on obesity in amle and in female Hellstrom,L.;Larger,V.;Reynisdottir,S.;Wahrenberg,H.;Arner,P. https://doi.org/10.1046/j.1365-2796.1999.0437e.x
  12. Am. J. Hypertens. v.13 β2-adrenergic receptor polymorphisms at codon 16, cardiovascular phenotypes and essential hypertension in Whites and African Americans Herrmann,V.;Buscher,R.;Go,M.M.;Ring,K.M.;Hofer,J.K.;Kailasam,M.T.;OConner,D.T.;Parmer,R.J.;Insel,P.A. https://doi.org/10.1016/S0895-7061(00)01188-2
  13. Theor. Appl Gnet. v.38 Linkage disequilibrium of finite population Hill,W.G.;Robertson,A. https://doi.org/10.1007/BF01245622
  14. J. Hypertension v.18 β₂-adrenoceptor gene polymorphisms and blood pressure vareations in East Anglian Caucasians Jia,H.;Sharma,P.;Hopper,R.;Dickerson,c. Lioyd,D.D.;Brown,M.J. https://doi.org/10.1097/00004872-200018060-00005
  15. Hypertension v.32 Linkage of α-adrenergic responsiveness to chromosome 5q in hypertensive families Kailisam,M.T.;Diggle,K.;Wilson,A.F.;O'Connor,D.T;Parmer,R.J.
  16. Environmental Mutagens and Carcinogens v.22-1 Genetic Variation of Eight Candidate Genes for Obesity in Korean population Kang,B.Y.;Bae,J.S.;Kim,K.T.;Yoon,M-Y.;Lee,K.O.;Shin,J.H.;Lee,C.C.
  17. Proc. Natl. Acad. Sci. USA. v.84 cDNA of the human β-adrenergic receptor : a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor Kobika,B.K.;Dixon,R.A.;Frielle,T.;Dohlman,H.G.;Boianowski,M.A.;Sigal,I.S.;Yang-Fing,T.L.;Francke,U.;Caron,M.G.;Lefkowitz,R.J. https://doi.org/10.1073/pnas.84.1.46
  18. J. Biol. Chem. v.262 Delineation of the intronless nature of the genes for the human and hamster β2-adrenergic receptor and their putative promoter regions Kobika,B.K.;Frielle,T.;Dohlman,H.G.;Boianowski,M.A.;Dixon,R.A.;Keller,P.;Caron,M.G.;Lefkowitz,R.J.
  19. J. Hypertens v.13 Alleles of the human β2 adrenoceptor and their relation to slat sensitivity Kotanko,P.;Binder,A.;Skrabal,F.
  20. Hypertension v.30 Essential hypertension in African Caribbeans associates with a varient of the β2-adrenoceptor Kotanko,P.;Binder,A.;Tasker,J.;DeFreitas,P.;Kamdar,S.;Clark,A.J.L. https://doi.org/10.1161/01.HYP.30.4.773
  21. Genetics v.49 The interaction of selection and linkage. Ⅰ. General considerations: heterotic models Lewontin,R.C.
  22. Am. J. Respir. Crit. Care. Med. v.156 Polymorphisms of the β₂-adrenergic receptor and asthma Liggett,S.B. https://doi.org/10.1164/ajrccm.156.4.12tac-15
  23. J. Allergy Clin. Immunol. v.104 Molecular and genetic basis of b₂-adrenergic receptor function Liggett,S.B. https://doi.org/10.1016/S0091-6749(99)70272-1
  24. J. Clin. Invest. v.100 Association between genetic polymorphisms of the β2-adrenoceptor and response to albuterol in children with and without a history of wheezing Martinez,F.D.;Graves,P.E.;Baldini,M.;Solomon,S.;Erickson,R. https://doi.org/10.1172/JCI119874
  25. J. Biol. Chem. v.269 The peptide product of a 5 leader cistron in the β2 adrenergic receptor mRNA inhibits receptor synthesis Parola,A.L.;Kobika,B.K.
  26. Am. J. Respir. Cell. Mol. Biol. v.8 Mutations in the gene encoding for the β2-adrenergic receptor in normal and asthmatic subjects Reihsaus,E.;Innis,M.;Maclntyre,N.;Liggett,S.B. https://doi.org/10.1165/ajrcmb/8.3.334
  27. Molecular colning: a Laboratory Manual. (2nd Ed.) Sambrook,J.;Fritsch,E.F.;Maniatis,T.
  28. Ann Hum Genet. v.59 Monte Carlo tests for associations between diseases and alleles at highly polymorphic loci Sham,P.C.;Curtis,D. https://doi.org/10.1111/j.1469-1809.1995.tb01608.x
  29. Hypertension v.27 Association hypertension with β2- and α(2c10)-adrenergic receptor genotype Svetkey,L.P.;Timmons,P.Z.;Emovon,O.;Anderson,N.B.;Preis,L.;Chen,Y.T. https://doi.org/10.1161/01.HYP.27.6.1210
  30. Lancet v.350 Association between β2-adrenoceptor polymorphism and susceptibility to bronchodilator desensitisation in moderately severe stable asthmatics Tan,S.;Hall,I.P.;Dewar,J.;Dow,E.;Lipworth,B. https://doi.org/10.1016/S0140-6736(97)03211-X
  31. Kidney Int. v.53 β2 adrenoceptor genetic variation is associated with genetic predisposition to essential hypertension: the Bergen Blood Pressure Study Timmermann,B.;Mo,R.;Luft,F.C.;Gerdts,E.;Busjahn,A.;Omvik,P https://doi.org/10.1046/j.1523-1755.1998.00926.x
  32. J. Clin. Invest. v.95 Genetic polymorphisms of the β2-adrenergic receptor in nocturnal and nonnocturnal asthema. Evidence that Gly16 correlates with the nocturnal phenotype Turki,J.;Pak,J.;Green,S.A.;Martin,R.J.;Liggett,S.B. https://doi.org/10.1172/JCI117838
  33. Am. J. Respir. Crit. Care. Med. v.161 Association of β₂-adrenoceptor variants with bronchial hyperresponsiveness Ulbrecht,M.;Hergeth,M.T.;Wjst,M.;Heinrich,J.;Bickeboller,H.;Wichmann,H.-E.;Weiss,E.H. https://doi.org/10.1164/ajrccm.161.2.9902072
  34. Am. J. Hypertens. v.6 Genetic basis of familial dyslipidemia and hypertension: 15-year results from Utah Wilson,P.;DAgostino,R.;Levy,D.