Development of Direct Measurement Device for Alveolar Breath Carbon Monoxide

  • Jo, Wan-Kuen (Department of Environmental Engineering, Kyungpook National University) ;
  • Oh, Jee-Won (Department of Environmental Engineering, Kyungpook National University)
  • Published : 2002.12.01

Abstract

A novel portable device for the direct measurement of alveolar breath carbon monoxide (CO) was developed. The major components of the device include a mouthpiece, non-rebreathing two-way valve, Teflon tube, and CO dosimeter. An alveolar CO measurement can be completed within 1.5 min when using the proposed device and measurement protocol. Measurements could be read to the nearest 0.1 ppm. Humidity did not influence the CO measurements taken by the CO dosimeter, plus there were no problems associated with the recovery and carryover of CO through the device. The criterion for significance in statistical analyses was p< 0.05. The average recovery was 103 and 99% for recovery and carryover experiments, respectively. Test results using the proposed alveolar CO measurement system reflected a good reproducibility. This reproducibility was also supported by the finding that the relative standard deviations (RSDs) of the data sets were less than 7% for the loss experiment and less than 8% for the carryover experiment. Consequently, it would appear that the proposed device can be effectively applied to measure CO levels found in breath, thereby overcoming several disadvantages associated with the conventional bag and adsorbent tube sampling methods.

Keywords

References

  1. Akland, G.G., T.D. Hartwell, T.R. Johnson, and R.W. Whitmore (1985) Measuring human exposure to carbon monoxide in Washington, D.C. and Denver, Colorado, during the winter of 1982-1983, Environ. Sci. Technol., 19,911-918
  2. Apte, M.G., D.S. Cox, S.K. Hammond, and L.A. Gundel (1999) A new carbon monoxide occupational dosimeter: results from a worker exposure assessment survey, J. Expos. Anal. Environ. Epidemiol., 9, 546-559
  3. Cox, B.D. and M.J. Whichelow (1985) Carbon monoxide levels in the breath of smokers and nonsmokers: effect of domestic heating systems, Epidemiol. and Comm. Health, 39, 75-78
  4. Guyton, A.C. (1977) Basic human physiology: normal function and mechanism of disease, 2nd ed., Philadelphia, pp. 393 -438
  5. Hartwell, T.D, C.A. Clayton, R.M. Michie, R.W. Whitmore, H.S. Zelon, S.M. Jones, and D.A. Whitehurst (1984) Study of carbon monoxide exposure of residents of Washington, D.C. and Denver, Colorado, Part 1. Final report. RTI/2390/00-0IF, Research Triangle Institute, NC
  6. Jabara, J.W., T.J. Keefe, H.J. Beaulieu, and R.M. Buchan (1980) Carbon monoxide: dosimetry in occupational exposures in Denver, Colorado, Archs. Environ. Health, 35,198-204
  7. Jo, W.K and KW. Pack (2000) Utilization of breath analysis for exposure estimates of benzene associated with active smoking, Environ. Res., 83, 180-187
  8. Jones, J.G., M.F. Ellicott, J.B. Cadigan, and E.A. Gaensler (1958) The relationship between alveolar and blood carbon monoxide concentrations during breathholding, J. Lab. Clin. Med., 51, 553-564
  9. Lambert, W.E., S.D. Colome, and S.L. Wojcieshowski (1988) Application of end-expired breath sampling to estimate carboxyhemoglobin levels in community air pollution exposure assessments, Atmos. Environ., 22,2171-2181
  10. Lee, K and Y. Yanagisawa (1995) Sampler for measurement of alveolar carbon monoxide, Environ. Sci. Technol., 29, 104-107
  11. Raymer, J.H., K.W. Thomas, S.D. Cooper, D.A. Whitaker, and ED. Pellizzari (1990a) A device for sampling of human alveolar breath for the measurement of expired volatile organic compounds, J. Anal. Toxicol., 14,337-344
  12. Raymer, J. K Thomas, S. Cooper, and E. Pellizzari (1990b) VOC breath measurement study: alveolar breath method, Final Report on EPA Contract No. 68- 02-4544, W.A. II-40, Task 1
  13. Smith, N.J. (1977) End-expired air technique for determining occupational carbon monoxide exposure, J. Occ. Med., 19,766-769
  14. United States Environmental protection Agency (USEPA) (1991) Air quality criteria for carbon monoxide; Washington, DC; EPA-600/8-90-045A
  15. Verhoeff, A.P, H.C.M. van der Velde, J.S.M. Boleij, E. Lebret, and B. Brunekreef(1983) Detecting CO exposure by measuring CO in exhaled breath, Int. Arch. Occup. Environ. Health, 53, 167-173
  16. Wallace, L.A., J. Thomas, and D.T. Mage (1984) Comparison of end-tidal breath estimates based on exposure profiles of individuals in the Denver and Washington, D.C. area. Presented at the Annual Meeting of the Air Pollution Control Association, San Fransisco, CA; Paper No. 84-121.5
  17. Wallace, L.A., J. Thomas, D.T. Mage, and W.R. Ott (1988) Comparison of breath CO, CO exposure, and Coburn model predictions in the U.S.EPA Washington-Denver CO study, Atmos. Environ., 22, 2183-2193
  18. Wallace, L.A. (1983) Carbon monoxide in air and breath of employees in an underground office, J. Air Pollut. Control Assoc., 33, 678-682