Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Evaluation of Antimicrobial Activity of Farnesoic Acid Derivatives

  • Kim, Sang-Hee (Natural Products Research Institute, College of Pharmacy, Seoul national University) ;
  • Oh, Ki-Bong (Natural Products Research Institute, College of Pharmacy, Seoul national University, Graduate School of Agricultural Biotechnology, College of Agriculture & Life Science, Seoul National University)
  • Published : 2002.12.01
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Abstract

The biological activities of farnesoic acid derivatives against pathogenic fungi and bacteria were investigated. Farnesoic acid and its derivatives showed growth inhibitory activities against various bacteria. Among the compounds tested, geranylgeranoic acid (3) had potent antibacterial activity against Salmonella typhimurium, Proteus vulgaris, and Bacillus subtilis with minimum inhibitory concentration (MIC) in the range of $6.25-12.5{\mu}g/ml$. On the other hand, amide derivatives of farnesoic acid showed some antifungal activities. In particular, 3,7,11-trimethyl-dodeca-2,6,10-trienoic acid amide (5a) had a potent antifungal activity against Aspergillus niger, Candida albicans, and Trichophyton sp. with MIC in the range of $6.25-12.5{\mu}g/ml$.

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References

  1. Official Methods of Analysis of AOAC International (16th ed.) AOAC
  2. Science. v.227 Control of filament formation in Candida albicans by the transcriptional repressor TUP1 Brown,B.R.;A.D.Johnson
  3. Annu. Rev. Biochem. v.68 Sterols and isoprenoids: Signaling molecules derived from the cholesterol biosynthetic pathway Edwards,P.A.;j.Ericssion https://doi.org/10.1146/annurev.biochem.68.1.157
  4. J. Biol. Chem. v.275 Farnesol.stimulates differentiation in epidermal keratinocytes via PPAR Hanley,K.;L.G.Konuves;D.C.Ng;K.Schoonjans;S.S.He;P.Lau;D.D.Bikle;M.L.Williams;P.M.Elias;J.Auwerx;K.R.Feingold https://doi.org/10.1074/jbc.275.15.11484
  5. Metabolism. v.50 Inhibition effect of new farnesol derivatives on all-trans-retinoic acid metabolism Kim,S.Y.;C.Kim;I.S.Han;S.C.Lee;S.H.Kim;K.S.Lee;Y.Choi;Y.Byun https://doi.org/10.1053/meta.2001.27190
  6. Bioorg. Med. Chem. Lett. v.12 Evaluation of morphogenic regulatory activity of farnesoic acid and its derivatives against Candida albicans dimorphism Kim,S.;E.Kim;D.S.Shin;H.Kang;K.B.Oh https://doi.org/10.1016/S0960-894X(02)00038-0
  7. J. Microbiol. Biotechnol. v.10 IL-6 mRNA expression in mouse macrophages and NIH 3T3 fibroblasts in response to Candida albicans Lee,Y.S.;H.S.Kim;S.K.Kim;S.D.Kim
  8. NCCLS Document M27-P Reference method for broth dilution antifungal susceptibility testing of yeasts; Proposed standard National Committee for Clinical laboratory Standards;National Committee for Clinical laboratory Standards (ed.)
  9. Proc. Natl. Acad. Sci. USA v.98 Purification and characterization of an autoregulatory substance capable of regulating the morphological transition in Candida albicans Oh,K.B.;H.Miyazawa;T.Naito;H.Matsuoka https://doi.org/10.1073/pnas.071404698
  10. J. Microbiol. Biotechnol. v.11 In vitro activities of 2,2-dipyridyl against Trichomonas vaginalis, Candida albicans, and Gardnerella vaginalis Ryu,J.S.;D.Y.Min;M.C.Kim;N.S.Kim;M.H.Shin
  11. Science. v.277 Creating isoprenoid diversity Sacchettini,J.C.;C.D.Polter https://doi.org/10.1126/science.277.5333.1788
  12. Biochim. Biophys. Acta v.1529 Sterols and gene expression: control of affluence Schoonjans,K.;C.Brendel;D.Mangelsdorf;J.Auwerx https://doi.org/10.1016/S1388-1981(00)00141-4
  13. Insect. Biochem. Mol. Biol. v.31 Farnesol wxidation in insects: Evidence that the biosynthesis of insect juvenile hormone is mediated by a specific alcohol oxidase Sperry,A.E.;S.E.Sen https://doi.org/10.1016/S0965-1748(00)00115-6
  14. J. Bone Miner. Res. v.17 Effects of geranylgeranoic acid in bone: Induction of osteoblast differentiation and inhibition of osteoclast formation Wang,X.;J.Wu;Y.Shidoji;Y.Muto;N.Ohishi;K.Yagi;S.Ikegami;T.Shinki;N.Udagawa;T.Suda;Y.Ishimi https://doi.org/10.1359/jbmr.2002.17.1.91
  15. J. Biol. Chem. v.274 Interaction of the cyclic antimicrobial cationic peptide bactenecin with the outer and cytoplasmic membrane Wu,M.;R.E.W.Hancocks https://doi.org/10.1074/jbc.274.1.29