Korean Journal of Veterinary Service (한국동물위생학회지)

The Korean Society of Veterinary Service (한국동물위생학회)
권호 표지

Paramyxoviridae -Classification, structure, genomes and their encoded proteins-

파라믹소바이러스 -분류, 구조, 게놈 및 코드화된 단백질-

  • 송희종 (전북대학교 수의과대학 및 생체안전성연구소) ;
  • 어성국 (전북대학교 수의과대학 및 생체안전성연구소) ;
  • 채효석 (전북대학교 수의과대학 및 생체안전성연구소)
  • Published : 2002.06.01
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Abstract

파라믹소바이러스과 (Parnxouiridae) 바이러스는 외피당단백질의 생물학적 특성에 있어서 Orthomyxoviridae와, 분절되지 않은(nonseg-mented)게놈과 그 발현의 구성 측면에서 Rhbdoviridae와 유사성을 갖는 바이러스로서 외피로 둘러 싸여 있는 마이너스쇄(negative strand) RNA 바이러스이다. 마이너스쇄 RNA 바이러스의 게놈 RNA는 2가지 기능으로 작용한 다. 즉, 첫째는 mRNA 합성을 위한 주형(鑄型, template)으로 작용하고, 둘째는 플러스쇄 (anti-genome(+) strand)의 합성을 위한 주형으로서 작용한다. 마이너스쇄 RNA바이러스는 그들 자신의 RNA전사효소를 코드화 하여 저장하지만, mRNA는 감염세포 내에서 게놈이 노출된 후에만 합성된다. 바이러스 복제는 mRNA의 합성후 일어나며 연속된 바이러스단백질의 합성을 필요로 한다. 새로 합성된 플러스쇄(antigenome(+)strand)는 마이너스쇄 게놈 RNA의 복제를 도모하기 위한 주형(鑄型)으로서 작용한다.

Keywords

References

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