Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
권호 표지

Comparative Analysis of Obesity by $\beta$-II, III, Adrenergic Receptor Gene Polymorphism in Korean Young Females

$\beta$-II, III Adrenergic Receptor 유전자 다형성에 따른 20대 한국여성의 식이 섭취량, 비만도 및 체성분의 비교연구

  • Published : 2002.10.01
Download PDF
⟨ Previous Next ⟩

Abstract

The purpose of this study was to investigate the obesity and state of dietary intake of 216 young Korean females, and the influence of $\beta$-II, III Adrenergic receptor (AR) gene polymorphism upon obesity and dietary intake. The average weight, height and BMI of the subjects were 160 cm, 54 kg, and 20.9 kg/$m^2$, respectively. The average triceps skinfold thickness, waist circumference, hip circumference and WHR were 21.7mm, 73.1cm, 93.3cm and 0.78, respectively. The results of body composition measurement using bioimpedance method, average body fluid, body protein, mineral mass and body fat were 29.271, 7.22 kg, 6.79 kg and 19.16 kg, respectively. A dietary survey was conducted using 24-hour recall method. Average calorie intake was 1621 ㎉, which is 81% of Korean RDA. We detected 182 (84.3%) Gln27 (QQ) homozygotes and 34 (15.7%) Gln27Glu (QE) heterozygotes for $\beta$-II AR polymorphism. For $\beta$-III AR polymorphism, we detected 163 (75.5%) Trp64 (WW) and 53 (24.5%) Trp 64Arg (WR). The results of comparing of obesity by $\beta$-II AR gene polymorphism, obesity index and BMI of QE type were slightly higher than those of the QQ type. For $\beta$-III AR gene polymorphism, the mean BMI, obesity index, fat mass and percent body fat (%) of the WR type were significantly higher than those of the WW type (p < 0.05). These findings suggest that genetic variability in the human $\beta$-III AR is associated with obesity among young Korean females. We also evaluated the effect of the simultaneous presence of the $\beta$-II AR and $\beta$-III AR polymorphism on obesity. We found that the BMI and obesity index of the mutant type in both $\beta$-II AR and $\beta$-III AR were significantly higher than those of the type that has only one gene mutation or has no mutation (p < 0.05), indicating a synergistic effect of $\beta$-II AR and $\beta$-III AR polymorphism on obesity. No association was found between $\beta$-II Ad or $\beta$-III AR polymorphism and dietary intake.

Keywords

References

  1. Journal of Korean Society for the Study of Obesity v.6 no.1 Abnormality in β3 Adrenergic Receptor Kim YS
  2. J Inter Med v.245 no.6 Adrenoreceptor genes in human obesity Arner P;Hoffsitedt J https://doi.org/10.1046/j.1365-2796.1999.00495.x
  3. Nature v.393 Human gene for physical performance Montgomery HE https://doi.org/10.1038/30374
  4. Biochemical and Biophysical Research Communication v.232 Association of a genetic-variation n the β3-adrenergic receptor gene with coronary heart disease among Japanese Kenji H;Toshitsugu I;Toshimitsu I;Atsushi Y;Hidelci S;Haruo N https://doi.org/10.1006/bbrc.1997.6339
  5. The England Journal of Medicine v.333 Association of a polymorphism in the β3-adrenergic receptor gene with features of the insulin resistance syndrome in Finns Elisaneth W;Markku L;Timo K;Jeremy W;Alan RS;Lief CG
  6. Br J Clin Pharmacol v.48 no.5 Population frequency, mutation linkage and analytical methodology for the Arg16Gly, Gln27Glu and Thr164Ile polymorphism in the beta-3 adrenero receptor among Turks Aynacioglu AS;Cascorbi I;Gungor K;Ozkur M;Bekir N;Roots I;Brockmoller J https://doi.org/10.1046/j.1365-2125.1999.00082.x
  7. Biochemical and Biophysical Research Communications v.15 no.2 A mutation in the β 3-adrenergic receptor gene is associated with obesity and hyperinsulinemia in Japanese subjects Hiroko K;Kazuki Y;Keishi I;Shuichi O;Kotaro S;Kristi S;Jeremy W;Hideo Y;Kinori K;Nobuhiro Y;Yasushi S;Ryoko H;Yasuo A;Alan S;Yoshio Y;Takashi K
  8. Diabetes v.48 Polymorphism of the Human β3-Adrenoceptor gene forms a well-conserved haplotype that is associated with moderate obesity and altered receptor function Jahan H;Odette P;Anders T;Fredrik L;Stefan M.H;Fancois C;Peter Arner https://doi.org/10.2337/diabetes.48.1.203
  9. Clinca Chimica Acta v.274 Association of the Trp64Arg mutation of the β3-adrenergic receptor with fatty liver and mild glucose intolerance in Japanese subjects Yukio S;Toshihiko T;Koji N;Hidehiko O https://doi.org/10.1016/S0009-8981(98)00059-X
  10. International Journal of Obesity v.20 Polymorphism of the β3-adrenergic receptor gene in morbid obesity Oksanen I;Mustajoki P;Kaprio J;Kainulatnen K;Janne O;Kontula K
  11. J of Clin Endoc and Metabol v.82 no.4 Lack of association between the Trp64Arg Mutation in the β3-Adrenergic receptor gene and obesity in Japanese Men: A Longitudinal analysis Terumasa N;Akira A;Michiko Y;Hiroko Y;Seijiro K;Miyuki N;Nobuo K;Takuhiko A;Naokazu N
  12. Diabetes v.45 Insulin sensitivity and body weight changes in young white carriers of the codon 64 amino acid polymorphism of the β3-adrenergic receptor gene Soren AU;Jesper OC;Torben H;Oluf P https://doi.org/10.2337/diabetes.45.8.1115
  13. The New Eng J Med v.333 no.10 Genetic variation in the β3 adrenergic receptor and increased capacity to gain weight in patients with morbid obesity Karine C;Christian V;Brian SJ;Arnard B;Bernard GG;Juan R;Kristi D;Silver R
  14. Metabolism v.48 no.5 Relation of β3-adrenergic receptor gene mutation to total body fat but not percent body fat and insulin levels in Thais Boongsong O;Rajata R;Suwannee C;Noppawan P;Laor C;Surat K;Pongamorn B;Gobehai P https://doi.org/10.1016/S0026-0495(99)90051-3
  15. Diabetologia v.40 β3-adrenergic-receptor polymorphism: a genetic marker for visceral fat obesity and the insulin resistance syndrome Sakane N;Yoshida T;Umekawa T;Kondo M;Sakal Y;Takahashi T https://doi.org/10.1007/s001250050663
  16. Metabolism v.47 no.5 The Trp64Arg Mutation of the β3-Adrenergic Receptor is associated with hyperglycemia and current body mass index in Jamaica Women Norma MA;Franklyn B;Rsinford W;Sharon H;Cavelle N;Kenedy C;Terrence F https://doi.org/10.1016/S0026-0495(98)90249-9
  17. J Clin Invest v.101 no.3 A paired silbling analysis of the beta-3 adrenergic receptor and obesity in Mexican Americans Braxton DM;John B;Anthony GC;Laura AA;Alan RS;Kristi S;Michael PS;Jean M;James EH https://doi.org/10.1172/JCI512
  18. Clinical and Experimental Pharmacology and Physiology v.24 Expression of the β3-adreneroreceptor gene polymorphism (Trp64Arg) in obese diabetic and non-diabetic subjects Cheryl LJ;Janet MB;Jan DC;Dennis KY;Richard D https://doi.org/10.1111/j.1440-1681.1997.tb02122.x
  19. Diabetologia v.40 A mutation of the β3-adrenergic receptor is associated with viesceral obesity but decreased serum triglyceride Motoyama HK;Yasuda K;Yamaguchi T;Yamada N;Katakura:Alan RS;Akanuma Y;Ohashi Y;Yazaki Y;Kadowaki; https://doi.org/10.1007/s001250050702
  20. The J Clin Endo & Meta v.64 no.6 Trp64Arg polymorphism of the β3-adrenergic receptor gene in Pregnancy association with mild gestational Diabetes Mellitus Andreas F;Malter K;Nadja S;Pierre H;Steven M;Haffner;Guntram scherntheaner
  21. Biochemical and Biophysical Research Communications v.258 The Gln27Glu β2-Adrenergic receptor variant is associated with obesity with to subcutaneous fat accumulation in japanese men Yasumichi M;Hoon KM;Yoichi I;Yomiyoshi K;Kazuki Y;Satomi IS;Kentaro Y;Yasuo A;Yasuo O;Satoshi K;Yoshio Y;Takashi K https://doi.org/10.1006/bbrc.1999.0607
  22. Metabolism v.49 no.8 Interactions among the alpha 2-, beta 2-, and bets 3- adrenergic receptor genes and obesity-related phenotypes in the Quebec Family Study Ukkola O;Rankinen T;Weisnagel SJ;Sun G;Peruse L;Chagnon YC;Despres JP https://doi.org/10.1053/meta.2000.7708
  23. The Journal of Clinical Endocrinology & Metabolism v.84 no.5 Polymorphism in the 5'-leader cistron of the β2-adrenergic receptor gene associated with obesity and type 2 diabetes Kentaro Y;Satomi IS;Fumi I;Xiaohong Y;Atsuko K;Wasaku K;Kyohei N https://doi.org/10.1210/jc.84.5.1754
  24. Journal of Internal Medicine v.247 The Q/E27 polymorphism in the β2-adrenenoceptor gene is associated with increased body weight and dyslipoproteinaemia involving triglyceride-rich lipoproteins Ehrenborg E;Skogsberg I;Rutolo G, Large;Eriksson P;Arner, Hamsten A https://doi.org/10.1046/j.1365-2796.2000.00669.x
  25. J Clin Invest v.100 Human beta-2 afrenoceptor gene polymorphisms are highly frequent in Obesity and associate with Altered Adipocyte Beta-2 adrenoceptor function Valerie L;Lena H;Signy R;Fredrik L;Per E;Lars L;Peter A https://doi.org/10.1172/JCI119854
  26. International Journal of Obesity v.24 Impact of polymorphisms of the human β2-adrenoceptor gene on obesity in a French population Meirhaegche A;Hetheeque N;Cottel D;Amouyel P https://doi.org/10.1038/sj.ijo.0801168
  27. Am J Clin Nutr v.46 Methods for the assessment of human body composition: Traditional View Lukaski HC https://doi.org/10.1093/ajcn/46.4.537
  28. A Comparative Study J Appl Physiol v.58 Estimation of human body composition by electrical impedance methods Segal KR;Gutin B;Presta E;Wang J;van Itallie TB
  29. Korean J Nutrition v.28 no.9 A Longitudinal Study on Seasonal Variations of Physical Activity and Body Composition of Rural Women Lim HJ;Youn JS
  30. Eur J Clin Nutr v.45 Critical evaluation of energy intake data using fundamental principles of energy physiology: 1. Derivation of cut-off limits to identify under-recording Golberg GR;Black AE;Jebb SA;Cole TJ;Murgatroyd PR;Coward WA;Prentice AM
  31. Korean J Nutrition v.32 no.8 Under-reporting in dietary assessment by 24-hour recall method in Korean female college students Lee EY;Kim JH;Paik HY
  32. Recommended dietary allowances for Koreans(7th revision)
  33. Energy and Protein requirement FAO/WHO/UNU expert consulation
  34. Principle of statistics Lee SY
  35. J Korean Home Economics Association v.32 no.2 Weight concerns and eating patterns of college women Lee YM;Lee KW
  36. J Korean Dietetic Association v.7 no.2 A study of age-related patterns in body composition by using segmental bioelectrical impedance analysis for Koreans Shon CM;Kim JH;Shin SY;Cha KC
  37. Korean J Nutrition v.32 no.2 Relationships among fasting serum insulin, free fatty acid, lipid levels and anthropometric measurements in female college students Kim SY;Kim SH;Lim SS
  38. Family Physician v.10 no.8 The study on the blood pressure of some public service personnel Kim DS;Cho KJ;Choi KJ;Hong MH
  39. Obesity Paik SK
  40. Korean J Dietary Culture v.11 no.5 Survey on food consumption patterns and untrients intakes of college students by body mass index Choi JH;Wang SK
  41. Korean J Nutrition v.34 no.5 Comparative analysis and evaluation of dietary intakes of Koreans by age groups (1) nutrient intakes Shim JE;Paik HY;Moon HK;Kim YO
  42. Korean J Nutrition v.34 no.5 Comparative analysis and evaluation of dietary intakes of Koreans by age groups (2) food and food group intakes Shim JE;Paik HY;Moon HK;Kim YO
  43. Journal of the Korean Dietetic Association v.7 no.1 The relation between nutrient intakes and blood parameters of cardiovascular function of female college students in chungnam Choi MK;Jun YS;Sung CJ;Lee PH;Kim MH
  44. Diabetologia v.39 Association of Trp64Arg mutation of the β3-adrenergic receptor with NIDDM and body weight gain Fujisawa T;Ikegami H;Yamain E;Takekawa K;Nakagawa Y;Hamada Y;Oga T;Ueda H;Shintani M;Fukuda M;Ogihara T https://doi.org/10.1007/BF00418352
  45. Obesity Research v.9 no.2 The human obesity gene map: The 2000 update Louis Perusse;Yoon CCS;John Weisnagel;Tuomo R;Eric S;John S;Claude B https://doi.org/10.1038/oby.2001.17