Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
권호 표지

Effects of Isoflavones Supplementation on Bone Mineral Density and Sex Hormones in Postmenopausal Women

이소플라본 보충이 폐경 후 여성에서 골밀도와 성호르몬에 미치는 영향

  • 이다홍 (숙명여자대학교 식품영양학과) ;
  • 김미현 (숙명여자대학교 식품영양학과) ;
  • 윤미은 (숙명여자대학교 식품영양학과) ;
  • 승정자 (숙명여자대학교 식품영양학과) ;
  • 이행신 (한국보건산업진흥원 보건의료사업단)
  • Published : 2002.10.01
Download PDF
⟨ Previous Next ⟩

Abstract

Soy isoflavones have been hypothesized to exert hormonal effects and to enhance bone mineral density in postmenopausal women. To test this hypothesis, we studied the effects of soy isoflavones supplements on bone mineral density and sex hormones (serum estradiol, sex hormone-binding globulin and testosterone) in 47 postmenopausal women. There were 24 participants in the treatment group and 23 in the control group. The treatment group consumed the isoftavones extract capsule daily (which contained 90 mg of soy isoflavones) for 12 weeks. The study compared pre- and post-isoflavones intake in the following areas: physical examination, diet survey, bone mineral density and serum sex hormone levels. The average age of the treatment group was 64.63 years and that of the control group was 66.48 years. There were no significant differences between the two groups in terms of height, weight, and body mass index. Both groups maintained regular diet patterns in terms of their average daily nutrient intake. There was no significant difference between the treatment group (18.49 mg) and the control group (21.27 mg) in terms of daily isoflavones intake based on diet. The 12-week analysis of bone mineral density change after taking isoflavones supplements demonstrated no significant differences in the following : lumbar spine BMD (0.82 g/$\textrm{cm}^2$ in pre versus 0.81 g/$\textrm{cm}^2$ in post), femoral neck BMD (0.58 g/$\textrm{cm}^2$ in pre versus 0.57 g/$\textrm{cm}^2$ in post) in the treatment group. There was no significant difference in serum estradiol in the isoflavones treatment group. The subjects indicated no significant difference in serum testosterone in the isoflavones treatment group. But the subjects indicated a significant difference in sex hormone-binding globulin (60.04 nmol/L in pre versus 52.39 nmol/L in post) in the isoflavones treatment group at the levels of p < 0.05. The significant decrease in sex hormone-binding globulin did indicate the need for long-term study on isoflavones supplementation as well as its positive effect on bone mineral density.

Keywords

References

  1. Canadian Medical Association v.166 no.8 Clinical practice guidelines for the care and treatment of breast cancer: 14. The role of hormone replacement therapy in women with a previous diagnosis of breast cancer Pitchard KI;Khan H;Levine M
  2. Aust Fam Physician v.31 no.5 Controversies in hormone replacement therapy Teede HJ
  3. Endocrinology v.139 Interaction of estrogenic chemicals and phytoestrogen receptor β Kuiper G;Lemmen J;Carlsson B(et al) https://doi.org/10.1210/en.139.10.4252
  4. KOREA SOYBEAN SOCIETY ISSN v.15 no.2 Soyfoods, soybean isoflavones, and bone health Messina M
  5. Am J Clin Nutr v.68 no.suppl Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women Potter SM;Baum JA;Teng H;Stillman RJ;Shay NF;Erdman Jr JE https://doi.org/10.1093/ajcn/68.6.1375S
  6. Am J Clin Nutr v.72 Isoflavone-rich soy protein attenuates bone loss in the lumbar spine of perimenopausal women Alekel DL;Germain A;Peterson CT;Hanson HB;Stewart JW;Toda T https://doi.org/10.1093/ajcn/72.3.844
  7. J Nutr v.130 Daidzein is more efficient than genistein in preventing ovariectimy-induced bone loss in rats Picherit C;CoXam V;Bennetau-Pelissero C;Kati CS;Davicco M;Lebecque P;Barlet J https://doi.org/10.1093/jn/130.7.1675
  8. J Nutr Sci Vitaminol v.40 Evalution of the effect of soybean milk peptide on bone metabolism in the rat model with ovariectomized osteoporosis Omi N;Aoi S;Murata K;Ezawa I https://doi.org/10.3177/jnsv.40.201
  9. American Society for Nutritional Sciences Dietary Genistein Exerts Estrogenic Effects upon the Uterus, Mammary Gland and the Hypothalamic/Pituitary Axis in Rats Santell RCI;Chang YC;Nair MG;Helferich WG
  10. Menopause v.4 Short-term effects of phytoestrogen-rich diet on postmenopausal women Brzezinski A;Adlercreutz H;Shaoul R;Rosler A;Shmueli A;Tanos V;Schenker JG
  11. Cancer Epidemiol Biomarkers Prev v.5 Stimulatory influence of soy protein isolate on breast secretion in pre- and postmenopausal women Petrakis NL;Barnes S;King EB;Lowenstein J;Wiencke J;Lee MM;Miike R;Kirk M;Coward L
  12. J Clin Endocrinol Metab v.80 no.5 Dietary intervention study to assess estrogenicity of dietary soy among postmenopausal women Baird DD;Umbach DM;Lansdell L;Hughes CL;Setchell KD;Weinberg CR;Haney AF;Wilcox AJ;Mclachlan JA https://doi.org/10.1210/jc.80.5.1685
  13. J Clin Endocrinol Metab v.84 Modest Hormonal effects of Soy Isoflavones in Postmenopausal Women Duncan AM;Underhil KEW;Xu X;Lavalleur J;Phipps WR;Kurzer MS https://doi.org/10.1210/jc.84.10.3479
  14. J Agic Food Chem v.47 Isoflavones levels in soy foods consumed by multiethnic populations in Singapore and Hawaii Franke AA;Hankin JH;Yu MC;Maskarinec G;Low SH;Custer LJ https://doi.org/10.1021/jf9808832
  15. J Korean Soc Food Sci Nutr v.29 Estimated Isoflavones Intake from Soy Products in Korean Middle-aged Women Lee SK;Lee MJ;Yoon S;Kwon DJ
  16. Korean J Community Nutrition v.5 A Study on Dietary Isoflavones Intake from Soy Foods and Urinary Isoflavones Excretion and, Menopausal Symptoms in Korean Women in Rural Areas Sung CJ;Choi SH;Kim MH;Park MH;Ko BS;Kim HK
  17. J Nutr v.130 Intake of soy products is associated with better plasma lipid profiles in Hong Kong Chinese population Ho SC;Woo JL;Leung SSF;Sham ALK https://doi.org/10.1093/jn/130.10.2590
  18. Am J Clin Nutr v.54 Urinary excretion of lignans and isoflavonoid phytoestrogens in Japanese men and women consuming a traditional Japanese diet Adlercreutz H;Honjo H;Higashi A;Fotsis T;Hamalanen E;Hasegawa T;Okawa H https://doi.org/10.1093/ajcn/54.6.1093
  19. JAMA v.285 Ipriflavone in the treatment of postmenopausal osteoporosis Alexandersen P;Toussaint A;Christiansen C;Devogelaer J-P;Roux C;Fechtenbaum J;Gennari C;Reginster JY https://doi.org/10.1001/jama.285.11.1482
  20. 98 New Horizon of Osteoporosis (Osteoporosis Symposium) Calcitonin and Ipriflavon Jung YS
  21. Cancer Epidemiol Biomarkers Prev v.5 effects of soya consumption for one month on steroid hormones in premenopausal women: implications for breast cancer risk reduction Lu LJW;Anderson KE;Grady JJ;Nagamani M
  22. J Nutr v.130 hormonal effects of soy isoflavones: studies in premenopausal and postmenopausal women Kurzer MS https://doi.org/10.1093/jn/130.3.660S
  23. Annu Rev Nutr v.17 Dietary phytoestrogens Kurzer MS;Xu X https://doi.org/10.1146/annurev.nutr.17.1.353
  24. J Bone Miner Res v.15 Serum estrdiol and sex hormone-binding globulin and the risk of hip fracture in elderly women: the EPISODE study Chapurlat RD;Garnero P;Breart G;Meunier PJ;Delmas PD https://doi.org/10.1359/jbmr.2000.15.9.1835
  25. N Engl J Med v.339 Endogenous hormones and the risk of hip and vertebral fractures among older women. Study of Osteoporotic Fractures Research Groupp Cummings SR;Browner WS;Bauer D;Stone K;Ensrud K;Jamal S;Ettinger B https://doi.org/10.1056/NEJM199809103391104
  26. Nutr Cancer v.30 Usual consumption of plant foods containing phytoestrogens and sex hormone levels in postmenopausal women in Wisconsin Shoff SM;Newcomb PA;Mares-Perlman JA(et al) https://doi.org/10.1080/01635589809514665
  27. American Society for Reproductive Medicine v.77 Aromatization of androgens in women: current concepts and findings Simpson ER
  28. Clin Endocrinol v.30 Bone mass in hirsute women with androgen excess Dixon JE;Rodin A;Murby B;Chapman MG;Fogelman I https://doi.org/10.1111/j.1365-2265.1989.tb02235.x