The Korean Journal of Food And Nutrition (한국식품영양학회지)

The Korean Society of Food and Nutrition (한국식품영양학회)
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Effect of Protein and Threonine Level in the Diet on Liver Threonine Dehydrogenase Activity in Growing Rat

성장하는 랫트에 있어서 단백질과 Threonine의 급여 수준이 간 Threonine Dehydrogenase 활성에 미치는 영향

  • 이철원 (서울대학교 약학대학 위생화학교실)
  • Published : 2002.09.01
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Abstract

The aim of this investigation was to determine the influence of different protein and threonine (Thr) levels on the liver threonine dehydroaenase (TDG) activity b\ulcorner rats. In rats fed on CP (crude Protein) - diets, TDG activity was increased during an CP rise to 12.0% CP, decreased slightly down to 18.0% CP and showed .a trend to increase from 18.0 to 24.0% CP. In rats the feeding with graded Protein supply gavee no indication for additional stimulation of threonine-oxidation by TDG over a wide range of CP-content in the diets. The increase in threonine content from 0.28 to 0.72% in the presence of 12.0% CP caused a gradual increase in TDG activity in rat liver. This similarly applied to the feed admixed with 18.0% CP, but at a higher level.

랫트에 있어서 상이한 단백질과 threonine급여수준에 의한 간 TDG의 활성을 조사하였다. 식이 중의 단백질 급여수준과 TDG 활성과의 연계성을 조사하였을때, 12.0% CP까지는 TDG의 총활성이 단계적으로 상승하고, 더 높은 CP 함량 (18.0%∼24,0% CP)에 있어서는 경향적으로 threonine 분해의 쇠퇴가 나타났다. 전반적으로 단백질 함량의 증가에 의해 간 TDC를 통한 threonine의 산화가 증가하지 않았음을 나타내었다. 또 한식이 중의 단백질 및 threonine 급여수준과 TDG활성과의 연계성을 조사하였을 때, 단계적으로 상승시킨 threonine 급여수준이 (0.28∼0.72% Thr) 12.0% CP에 있어서 단계적으로 TDC활성을 상승시켰다. 또한 유사한 현상이 18.0%CP에 있어서도 관찰되었으며 약간 더 높은 TDG 활성을 나타내었다.

Keywords

References

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