Open Heart Surgery in Patient with Heparin- Induced Thrombocytopenia

헤파린 기인성 혈소판감소증 환자에서의 개심술

  • 송석원 (연세대학교 의과대학 심장혈관병원 심장혈관외과) ;
  • 홍유선 (연세대학교 의과대학 심장혈관병원 심장혈관외과) ;
  • 곽영란 (연세대학교 의과대학 마취과학 교실) ;
  • 안신기 (연세대학교 의과대학 내과학 교실)
  • Published : 2002.06.01

Abstract

A 45 year old man was admitted for aggravated dyspnea, abdominal distension and poor oral intake. On Echocardiogram, mitral stenosis(severe), tricuspid regurgitaion(IV), and LA thrombus were diagnosed. We used heparin with continuous infusion for prevention of systemic thrombo embolism. On the 11th day of admission, the patient showed thrombocytopenia and we suspected Heparin-induced thrombocytopenia. Hirudin was used in this case as alternative anticoagulant during cardiopulmonary bypass to prevent serious complication of heparin. The patient was recovered without any complication as postoperative bleeding or systemic thromboembolism.

42세 남자환자가 내원 3개월전부터의 호흡곤란, 복부팽만 및 식욕부진으로 내원하였다. 이학적 검사상 심잡음이 청진되어 심초음파를 시행한 결과, 좌심방 혈전을 동반한 승모판협착증 및 삼첨판폐쇄부전이 진단되어 수술전 헤파린 지속 주입을 시작하였다. 내원 11일째 혈소판수치가 감소하여 시행한 항체검사 및 혈소판응괴능 검사에서 음성이 나왔지만 임상적으로 헤파린 기인성 혈소판감소증을 진단하였다. 수술중 심폐우회술시 헤파린 대체약물인 히루딘(hirudin)을 사용하였으며, ACT, aPTT를 측정하며 수술대에서 육안적으로 혈전형성여부를 확인함으로써 성공적으로 수술을 하였다, 수술 중 및 수술 후 헤파린 접촉은 없었으며, 수술 후 과다 출혈 및 전신적 혈전색전증 등의 합병증은 발생하지 않았다.

Keywords

References

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