Parasites, Hosts and Diseases

The Korea Society for Parasitology and Tropical Medicine (대한기생충학·열대의학회)
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Apical membrane antigen-1 (AMA-1) gene sequences of re-emerging Plasmodium vivax in South Korea

  • Han, Eun-Taek (Department of Parasitology, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National University Medical Research Center) ;
  • Park, Jae-Hwan (Department of Parasitology, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National University Medical Research Center) ;
  • Shin, Eun-Hee (Department of Parasitology, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National University Medical Research Center) ;
  • Choi, Min-Ho (Department of Parasitology, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National University Medical Research Center) ;
  • Oh, Myoung-Don (Department of Internal Medicine, Seoul National University College of Medicine) ;
  • Chai, Jong-Yil (Department of Parasitology, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National University Medical Research Center)
  • Published : 2002.09.01
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Abstract

Plasmodium vivax malaria re-emerged in South Korea in 1993, and epidemics continue since then. We examined genetic variation in the region encompassing the apical membrane antigen-1 (PvAMA-1) of the parasites by DNA sequencing of the 22 re-emerging p. vivax isolates. The genotype of the PvAMA-1, which was based on sequence data previously reported for the polymorphic regions, showed that two haplotypes were present at one polymorphic site. Compared with reported data, the two types, SKOR type I and type II, were similar to Chinese CH- l0A and CH-05A isolates, respectively. Thus, the present study showed that two genotypes of AMA-1 genes coexist in the re-emerging Korean P. vivax.

Keywords

References

  1. Ampudia E, Patarroyo MA, Patarroyo ME, Murillo LA (1996) Genetic polymorphism of the Duffy receptor binding domain of Plasmodium vivax in Colombian wild isolates. Mol Biochem Parasitol 78: 269-272
  2. Chai IH, Lim GI, Yoon SN, Oh WI, Kim S, Chai JY (1994) Occurrence of tertian malaria in a male patient who has never been abroad. Korean J Parasitol 32: 195-200
  3. Chai JY (1999) Re-emerging Plasmodium vivax malaria in the Republic of Korea. Korean J Parasitol 37: 129-143
  4. Chai JY, Park YK, Guk SM, et al. (2000) A trial for a DNA diagnosis of Plasmodium vivax malaria recently reemerging in the Republic of Korea using microtiter plate hybridization assay. Am J Trop Med Hyg 63: 80-84
  5. Cheng Q, Saul A (1994) Sequence analysis of the apical membrane antigen I (AMA-1) of Plasmodium vivax. Mol Biochem Parasitol 65: 183-187
  6. Cheng Q, Stowers A, Huang TY, Rzepczyk C, Saul A (1993) Polymorphism in Plasmodium vivax MSA1 gene-the result of intragenic recombinations? Parasitology 106: 335-345
  7. Figtree M, Pasay CJ, Slade R, et al. (2000). Plasmodium vivax synonymous substitution frequencies, evolution and population structure deduced from diversity in AMA 1 and MSP 1 genes. Mol Biochem Parasitol 108: 53-66
  8. Galinski MR, Barnwell JW (1996) Plasmodium vivax: merozoites, invasion of reticulocytes, and considerations for malaria vaccine development. Parasitol Today 12: 20-29
  9. Kho WG, Park YH, Chung JY, et al. (1999) Two new genotypes of Plasmodium vivax circumsporozoite protein found in the Republic of Korea. Korean J Parasitol 37: 265-270
  10. Kho WG, Chung JY, Sim EJ, Kim DW, Chung WC (2001) Analysis of polymorphic regions of Plasmodium vivax Duffy binding protein of Korean isolates. Korean J Parasitol 39: 143- 150
  11. Li J, Collins WE, Wirtz RA, Rathore D, Lal A, McCutchan TF (2001) Geographical subdivision of the range of the malaria parasite Plasmodium vivax. Emerg Infect Dis 7: 35-42
  12. Lim CS, Kim SH, Kwon SI, Song JW, Song KJ, Lee KN (2000) Analysis of Plasmodium vivax merozoite surface protein-1 gene sequences from resurgent Korean isolates. Am J Trop Med Hyg 62: 261-265
  13. Lim CS, Kim YK, Lee KN, et al. (2001) The analysis of circumsporozoite-protein gene sequences from South Korean isolates of Plasmodium vivax. Ann Trop Med Parasitol 95: 229-235
  14. Miller LH, Good MF, Milon G (1994) Malaria pathogenesis. Science 264: 1878-1883
  15. Moon JJ, Cho SY (2001) Incidence patterns of vivax malaria in civilians residing in a highrisk county of Kyonggi-do (Province), Republic of Korea. Korean J Parasitol 39: 293-299
  16. National Institute of Health (2001) Epidemiology of malaria in Korea, 2000. Communicable Diseases Monthly Report (by National Institute of Health, Republic of Korea) 12(6)(suppl.): 5-10 (in Korean)
  17. National Institute of Health (2002) Statistics. Communicable Diseases Monthly Report 13(2): 31 (in Korean)
  18. Preiser PR, Kaviratne M, Khan S, Bannister L, Jara W (2000) The apical organelles of malaria merozoites: host cell selection, invasion, host immunity and immune evasion. Microbes Infect 2: 1461-1477
  19. Qari SH, Goldman IF, Povoa MM, Oliveira S, Alpers MP, Lal AA (1991) Wide distribution of the variant form of the human malaria parasite Plasmodium vivax. J Biol Chem 266: 16297-16300
  20. Qari SH, Goldman IF, Povoa MM, di-Santi S, Alpers MP, Lal AA (1992) Polymorphism in the circumsporozoite protein of the human malaria parasite Plasmodium vivax. Mol Biochem Parasitol 55: 105-113
  21. Rich SM, Ferreira MU, Ayala FJ (2000) The original of antigenic diversity in Plasmodium falciparum. Parasitol Today 16: 390-396
  22. Thompson, JD, Higgins DG, Gibson TJ (1994) CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, positionsspecific gap penalties and weight matrix choice. Nucl Acids Res 22: 4673-4680