Environmental Mutagens and Carcinogens (한국환경성돌연변이발암원학회지)

Korean Environmental Mutagen Society (한국환경성돌연변이발암원학회)
권호 표지

SNP Analysis of the Human LDL Receptor and CETP Gene in Korean Subjects with Hypertension

  • Shin, Jae-Hyun (School of Biological Science, Seoul National University) ;
  • Kang, Byung-Yong (Seoulin Bioscience Institute, Seoulin Biosicence, Co., Ltd.) ;
  • Lee, Kang-Oh (Dept. of Life Science, Sahmyook University) ;
  • Eo, Hyun-Shun (School of Biological Science, Seoul National University) ;
  • Bae, Joon-Seol (Seoulin Bioscience Institute, Seoulin Bioscience, Co., Ltd.) ;
  • Kim, Ki-Tae (Seoulin Bioscience Institute, Seoulin Biosicence, Co., Ltd.) ;
  • Kim, Hyun-Sup (Dept. of Biological Education, Kongju National University) ;
  • Lee, Chung-Choo (School of Biological Science, Seoul National University, Laboratory of Biology, Gachon Medical School)
  • Published : 2002.03.01
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Abstract

Essential hypertension is complex disorder influenced by multiple genetic and environmental factors. Alterations of lipid metabolism in plasma have been reported to be related to an increased risk of essential hypertension. The aim of this study was to investigate the relationship between two SNPs of the human LDL receptor and CETP gene and hypertension in Korean population. There were no significant differences in allele and genotype frequencies of two SNPs in normotensives and hypertensives. With respect to Hinc II RFLP in the LDL receptor gene, pooled odds ratio value indicated the significant heterogeneity among populations studied by meta-analysis (Breslow-Day test df = 2, P<0.05). In the case of Bam HI RFLP in the CETP gene,. our study is the first report of an association between the SNP of the CETP gene and hypertension, although our result failed to demonstrate the significant association between the Bam HI RFLP of the CETP gene and hypertension in Korean population. Further work, using larger sample sizes and various ethnic groups, is required to establish the precise role of these two candidate gene polymorphisms on hypertension.

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