Genetic Variations of Eight Candidate Genes in Korean Obese Group

  • Kang, Byung-Youn (Seoulin Bioscience Institute, Seoulin Biosicence, Co., Ltd., Dept. of Life Science, Sahmyook University) ;
  • Lee, Kang-Oh (Dept. of Life Science, Sahmyook University) ;
  • Bae, Joon-Seol (Seoulin Bioscience Institute, Seoulin Biosicence, Co., Ltd.) ;
  • Kim, Ki-Tae (Seoulin Bioscience Institute, Seoulin Biosicence, Co., Ltd.) ;
  • Yoon, Moon-Young (Dept. of Chemistry, Hanyang University) ;
  • Lim, Seok-Rhin (College of Oriental Medicine, Daejon University) ;
  • Seo, Sang-Beom (Genome Research Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Shin, Jung-Hee (School of Biological Science, Seoul National University) ;
  • Lee, Chung-Choo (School of Biological Science, Seoul National University, Laboratory of Biology, Gachon Medical School)
  • 발행 : 2002.03.01

초록

Obesity is a complex metabolic disorder with a strong genetic component. There are many candidate genes for obesity and its related phenotypes. We studied genetic variations between Korean obese and lean groups. Polymorphisms investigated were the Msp I polymorphism of the $\alpha$$_{2A}$-adrenergic receptor ($\alpha$$_{2A}$-AR) gene, the Mnl I polymorphism of the $\alpha$$_2$-adrenergic receptor ($\alpha$$_2$-AR) gene, the BstO I polymorphism of the $\beta$$_3$-adrenergic receptor ($\beta$$_3$-AR) gene, the Pml I polymorphism of the lamin A/C (LMNA) gene, the Hga I polymorphism of the clearance receptor (NPRC) gene, the Msp I polymorphism of the leptin gene, BclI polymorphism of the uncoupling protein 1 (UCPI) gene and the Hha I polymorphism of the fatty acid binding protein 2 (FABP2) gene. Among these genetic markers, Pml I polymorphism at the LMNA gene and Bcl I polymorphism at the UCP1 gene were significantly associated with obesity. However, further studies are required whether thease findings are reproduced in large population, although two polymorphisms might be useful as genetic markers in the ethiology of obesity in Korean population.ion.