Environmental Mutagens and Carcinogens (한국환경성돌연변이발암원학회지)
- Volume 22 Issue 1
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- Pages.22-29
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- 2002
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- 1225-6307(pISSN)
Two Genetic Polymorphisms of the Human Lipoprotein Lipase Gene in Korean Patients with Essential Hypertension
- Kang, Byung-Yong (Research Institute for Life Science, Sahmyook University) ;
-
Lee, Kang-Oh
(Department of Life Science, Sahmyook University)
;
- Kim, Ki-Tae (Seoulin Bioscience Institute, Seoulin Biosicence, Co., Ltd.) ;
- Bae, Joon-Seol (Seoulin Bioscience Institute, Seoulin Biosicence, Co., Ltd.) ;
-
Ryu, Jae-Chun
(Toxicology Lab., Korea Institute of Science and Technology)
;
- Kim, Jae-Hyoun (Dept. of Health Science, College of Natural Science, Dongduk Womens University) ;
- Lim, Seok-Rhin (College of Oriental Medicine, Daejon University) ;
- Lee, Chung-Choo (School of Biological Science, Seoul National University, Laboratory of Biology, Gachon Medical School)
- Published : 2002.03.01
Abstract
Essential hypertension is considered to be caused by a complicated combination of genetic and environmental factors. Alterations of lipid metabolism in plasma have been reported to be related to an increased risk of essential hypertension. The purpose of this study was to investigate the relationship between two genetic polymorphisms (Pvu II and Hind III RELPs) of the human lipoprotein lipase (LPL) gene and essential hypertension in korean population. In our result the Pvu II RFLP of LPL gene was significantly associated with essential hypertension (P < 0.05). Therefore, we suggest that the Pvu II RFLP of LPL gene may be useful as a genetic marker for essential hypertension in Korean population.