Biomolecules & Therapeutics

  • 제10권1호
  • /
  • Pages.7-11
  • /
  • 2002
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  • 1976-9148(pISSN)
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  • 2005-4483(eISSN)
한국응용약물학회 (The Korean Society of Applied Pharmacology)
권호 표지

SD랫드에서 (R)-JG-381의 단희경구독성시험

Single Oral Toxicity of (R)-JG-381 in Sprague-Dawley Rats

  • 이상호 (한국화학연구원 안전성연구센터) ;
  • 오우용 (한국화학연구원 안전성연구센터) ;
  • 김종춘 (한국화학연구원 안전성연구센터) ;
  • 주상섭 (서울대학교 약학대학) ;
  • 박형근 (서울대학교 약학대학) ;
  • 함광수 ((주)태평양제약 중앙연구소) ;
  • 조장섭 ((주)태평양제약 중앙연구소) ;
  • 이선미 (성균관대학교 약학대학)
  • 발행 : 2002.03.01
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초록

A single administration toxicity of (R)-JG-381 was studied in Sprague-Dawley rats of both sexes. In this study, rats were administered orally with dose of 50, 100, 200, 400 and 800 mg／kg of(R)-JG-381. We daily examined number of deaths, clinical signs, body weights and gross findings fur 14 days after (R)-JG-381 administration. When we administered different doses of 100, 200, 400 and 800 mg／kg, we found 5, 3, 5 and 5 male rats and 1, 4, 4 and 5 female rats dead within 1 day after administration, respectively. Some clinical signs(decrease of locomotor activity, decreased respiration rate, lacrimation, prone position) were observed during the experimental period. Our findings suggest that oral $LD_{50}s$(95% confidence limit) for male and female rats are 93.8mg／kg (28.8~161.6mg／kg) and 166.3mg／kg (89. I~284.8mg／kg), respectively.

키워드

참고문헌

  1. Agius, L., Mercdith, E. J. and Sherratt, H. S. (1991). Stereo-specificity of the inhibition by etomoxir of fatty acid and cholesterol synthesis in isolated rat hepatocytes. Biochem. Pharmacol. 9, 1717-1720
  2. Collier, G. R., Traianedes, K., Macaulay, S. L. and O'Dea, K-(1993). Effect of fatty acid oxidation inhibition on glucose metabolism in diabetic rats. Horm. Metab. Res. 25, 9-12 https://doi.org/10.1055/s-2007-1002035
  3. Ho, W., Tutwiler, G. F., Cottrell, S. C., Morgans, D. J., Tarhan, 0. and Mohrbacher, R. J. (1986). AIkylglycidic acids: potential new hypoglycemic agents. J. Med. Chem. 29, 2184-2190 https://doi.org/10.1021/jm00161a009
  4. Martin, C., Odeon, M., Cohen, R. and Beylot, M. (1991). Mecha-nisms of the glucose lowering effect of a camiline palmitoyl transferase inhibitor in normal and diabetic rats. Metabolism. 40, 420-427 https://doi.org/10.1016/0026-0495(91)90154-O
  5. Oh, W. Y., Lee, S. H., Kim, H. J., Jew, S. S., Park, H. G., Ham, K. S., Cho, J. S. and Lee, S. M. (2001). Single oral toxicity of JG-381 in rats. J Appl. Pharmacol. 9, 231-235
  6. Ratheiser, K.., Schneeweiss, B., Waldhausl, W., Fasching, P., Korn, A., Nowotny, P., Rohac, M. and Wolf, H. P. (1991). Inhibition by ctomoxir of camitine palmitoyltransferase I reduces hepatic glucose production and plasma lipids in non-insulin-dependent diabetes mellitus. Metabolism. 40, 1185-1190 https://doi.org/10.1016/0026-0495(91)90214-H
  7. Turcani, M. and RupP, H. (1999). Modification of left Ventri-cular hypertrophy by chronic etomixir treatment. Br. J. Pharmacol. 126, 501-507
  8. Wolf, H. P. (1992). Possible new therapeutic approach in diabetes mellitus by inhibition of carnitine Paimitoyltrans-ferase 1 (CPTl). Horm. Metab. Res. SuppI. 26, 62-67
  9. 식품의악품안전청(1999). 의약품등의 독성시힘기준, 식품의약품안전청고시 제1999-61호
  10. 식품의악품안전청(2000). 비임상시험 관리기준, 식품의약품안전청고시 제2000-63호