Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Cardiovascular Effects of Propofol Infused for Maintenance of Anesthesia in Dogs

개에서 Propofol 점적투여율 변화가 심혈관계에 미치는 영향

  • 권영삼 (경북대학교 수의과대학) ;
  • 장광호 (경북대학교 수의과대학) ;
  • 장환수 (경북대학교 수의과대학) ;
  • 박현정 (경북대학교 수의과대학) ;
  • 임재현 (경북대학교 수의과대학) ;
  • 오태호 (경북대학교 수의과대학) ;
  • 엄기동 (경북대학교 수의과대학) ;
  • 장인호 (경북대학교 수의과대학)
  • Published : 2002.06.01
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Abstract

Cardiovascular effects of propofol, were assessed after premedication with xylazine(1.0 mUkg, IM) under oxygen supply(200 ml/kg/min) via a endotracheal tube. Twelve adult mixed-breed dogs were divided into four groups; 0.2(Group 1), 0.4(Group 2), 0.6(Group 3) and 0.8 mg/kg/min(Group 4) of propofol respectively. Arterial blood pressure and electrocardiogram were monitored with a physiograph after an arterial catheter was inserted into the femoral artery. pH, arterial carbon dioxide tension($PaCO_2$and arterial oxygen tension($PaO_2$) were evaluated with arterial blood collected through the inserted catheter. Diastolic arterial pressure, systolic arterial pressure and mean arterial pressure were decreased slightly in Group I IIand III, but decreased significantly in Group IV. They were increased rapidly after stopping propofol infusion in Group IV pH was maintained in normal range in Group I, II and m, but was decreased in proportion to time passing in Group IV. $PaCO_2$ was increased significantly only in Group IV but $PaO_2$ was maintained in normal range in all groups Although heart rate was recorded in normal range for 90 minutes, arythmia was noted after stopping propofol infusion in all groups. It was concluded that propofol depressed the cardiovascular system in proportion to infusion dosage, and 0.8 mg/kg/min of propofol infusion rate was not appropriated in canine anesthesia with xylazine premedication.

Keywords

References

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