Preventive Nutrition and Food Science

  • 제7권2호
  • /
  • Pages.123-127
  • /
  • 2002
  • /
  • 2287-1098(pISSN)
  • /
  • 2287-8602(eISSN)
한국식품영양과학회 (The Korean Society of Food Science and Nutrition)
권호 표지
DOI QR코드

DOI QR Code

Inhibitory Effects of Ninety Nine Korean Plants on Human Immunodeficiency Virus Type 1 Pretense Activity

  • Park, Jong-Cheol (Department of Oriental Medicine Resources) ;
  • Hur, Jong-Moon (Department of Oriental Medicine Resources) ;
  • Park, Ju-Gwon (Department of Oriental Medicine Resources) ;
  • Hyun, Kyu-Hawn (Department of Resources Plants, Sunchon National University) ;
  • Lee, Kab-Yeon (Sobu Forest Experiment Station, Korea Forest Genetics Research Institute) ;
  • Hirotsugu Miyashiro (Institute of Natural Medicine, Toyama Medical and Pharmaceutical University) ;
  • Masao Hattori (Institute of Natural Medicine, Toyama Medical and Pharmaceutical University)
  • 발행 : 2002.06.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Ninety nine extracts from Korean plants were screened for their inhibitory activities on human immunodeficiency virus (HIV) type 1 pretense by an HPLC method. The pretense inhibitory activities were determined by incubating the extracts in reaction mixtures containing pretense and substrate (His-Lys-Ala-Arg-Val-Leu-(p-NO$_2$- Phe)-Glu-Ala-Nle-Ser-NH$_2$) to perform proteolytic cleavage reactions. Of the extracts tested, the water extracts of Viburnum awabuki (stem and leaves) and Distylium racemosum (leaves) had the highest pretense inhibitory activities at a concentration of 100ug/mL. Activity-guided fractionation, revealed that the n-butanol fraction of the V. awabuki extract and the ethyl acetate fraction from the D. racemosum extract had the greatest inhibitory activity on HIV-1 pretense.

키워드

참고문헌

  1. Pratt R. 1995. HIV & AIDS -A strategy for nursing care. 4th ed. Edward Arnold, London. p 11
  2. Kusumoto IT, Nakabayashi T, Kida H, Miyashiro H, Hattori M, Namba T, Shimotohno K.1995. Screening various plants extacts used in Ayurvedic medicine for inhibitory effects on human immunodeficiency virus type 1 protease. Phytother Res 9: 180-184 https://doi.org/10.1002/ptr.2650090305
  3. Shen Y, Ye W, Zhao S, Shu Y, Wataya M, Kakiuchi N, Hattori M, Matsuura K, Namba T. 1988. Isolation of two saponins from Anemone flaccida and their effects on reverse transcriptase. Shoyakugaku Zasshi 42: 35-40
  4. El-Mekkawy S, Meselhy RM, Kusumoto IT, Kadota S, Hattori M, Namba T. 1995. Inhibitory effects of Egyptian folk medicines on human immunodeficiency virus reverse transcriptase. Chem Pharm Bull 43: 641-648 https://doi.org/10.1248/cpb.43.641
  5. Kusumoto IT, Kakiuchi N, Hattori M, Namba T, Sutardjo S, Shimotohno K. 1992. Screening of some Indonesian medicinal plants for inhibitory effects on HIV-1 protease. Shoyakugaku Zasshi 46: 190-193
  6. Lim YA, Kida H, Miyaji M, Kusumoto IT, Miyashiro H, Hattori M, Shimotohno K, Gupta MP, Correa M. 1997. Inhibitory effects of some Panamanian plants on human immunodeficiency viral reverse transcriptase and protease. J Trad Med 14: 54-58
  7. Katoh I, Ikawa Y, Yoshinaka Y. 1989. Retrovirus protease characterized as a dimeric aspartic proteinase. J Virol 63: 2226-2232
  8. Robert NA. 1988. Rational design of peptide-based HIV protease inhibitors. Science 247: 358-361
  9. Kohl NE, Emini EA, Schiief WA. 1988. Active human im-munodeficiency virus protease is required for viral infectivity. Proc Natl Acad Sci USA 85: 4686-4690 https://doi.org/10.1073/pnas.85.13.4686
  10. Meek TD, Lambert DM, Metcalf BW, Petterway SR, Dreyer GB. 1990. HIV-1 protease as a target for potential anti-AIDS drugs. In Design of anti-AIDS drugs. DeClercq E, ed. Elsevier Science Publishers BV, The Netherlands
  11. Mous J, Heimer EP, Le Grice SFJ. 1988. Processing protease and reverse transcriptase from human immunodeficiency virus type 1 polyprotein in Escherichia coli. J Virol 62: 1433-1444
  12. Huff JR. 1991. HIV-1 protease : a novel chemotherapeutic target for AIDS. J Med Chem 34: 2305-2314 https://doi.org/10.1021/jm00112a001
  13. Larder BA, Kemp SD. 1989. Multiple mutations in HIV-1 reverse transcriptase confer high level resistance to zidovudine (AZT). Science 246: 1155-1158 https://doi.org/10.1126/science.2479983
  14. Fukuyama Y, Minami H, Yamamoto I, Kodama M, Kawazu K. 1998. Neouvibsanins H and I, novel diterpenes from Viburnum awabuki. Chem Pharm Bull 46: 545-547 https://doi.org/10.1248/cpb.46.545
  15. Fukuyama Y, Minami H, Ichikawa R, Takeuchi K, Kodama M. 1996. Hydroperoxylated quaiane-type sesquitrpenes from Viburnum awabuki. Phytochem 42: 741-746 https://doi.org/10.1016/0031-9422(96)00042-8
  16. Kagawa M, Minami H, Nakahara M, Takahashi H, Takaoka S, Fukuyama Y. 1998. Oleanane-type triterpenes from Viburnum awabuki. Phytochem 47: 1337-1341 https://doi.org/10.1016/S0031-9422(97)00742-5

피인용 문헌

  1. Peptide Inhibitor for Human Immunodeficiency Virus Type 1 (HIV-1) Protease from a Thermolysin Hydrolysate of Oyster Proteins vol.13, pp.1, 2010, https://doi.org/10.5657/fas.2010.13.1.084
  2. Inhibitory effects of Korean plant resources on human immunodeficiency virus type 1 protease activity vol.3, pp.1, 2003, https://doi.org/10.3742/OPEM.2003.3.1.001
  3. Isolation of HIV-1 Pretense Inhibiting Peptide from Thermolysin Hydrolysate of Manila Clam Proteins vol.8, pp.2, 2002, https://doi.org/10.3746/jfn.2003.8.2.154