응용통계연구 (The Korean Journal of Applied Statistics)

  • 제15권1호
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  • Pages.85-105
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  • 2002
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  • 1225-066X(pISSN)
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  • 2383-5818(eISSN)
한국통계학회 (The Korean Statistical Society)
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유전자검사자료의 통계분석을 위한 수량화 및 그래프 방법

Quantification and Graphical Method for DNA Fingerprinting

  • 박미라 (을지의과대학교 의예과)
  • 발행 : 2002.03.01
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초록

본 연구에서는 유전자 검사자료에서 각 유전자좌내 및 유전자좌간의 대립형질들간의 관계를 파악하기 위한 탐색적 방법을 고려하였다. 이를 위해 유전자데이터를 재배열한 후 대응분석 및 다중대응분석의 알고리즘을 적용하여 이를 수량화, 그래프화하는 방법 및 대응행렬도를 적용한 방법을 제안하였다 이러 한 수량화 및 그래프 결과가 하디-와인버그 평형검정 및 연관균형검정 결과와 어떤 관계가 있는지 알아보고 실제 한국인 집단에 대한 STR 유전자좌 자료를 이용하여 결과를 비교하였다.

To explore the relationships among frequencies for sets of alleles, within or between loci, is one of the first analyses in population genetic study. The general question is whether the frequency of a set of alleles is the same as the product of each of the separate allele frequencies. For two alleles of a single locus, Hardy-Weinberg equilibrium is tested and for an allele from each of two loci, linkage disequilibrium is tested. However, it is more useful if we can quantify and graphically represent this information. In this study, we suggest graphical methods to find associations between alleles. We also analyze the STR data of Korean population as an illustration.

키워드

참고문헌

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