A New Coumarin from the Stem of Angelica dahurica

  • Published : 2002.02.01

Abstract

One new and three known coumarins were isolated from the $CHCl_3$ soluble fraction of Angelica dahurica stem. On the basis of spectral data, the structures of the isolated compounds were determined to be scopoletin, angelol I, angelol H and 6-[(1S), 2(R)-2, 3-dihydroxy-1-methoxy-3-methylbutyl]-7-methoxycoumarin; the latter being isolated for the first time from a plant source.

Keywords

References

  1. Baba, K., Matsuyama, Y., and Kozawa, M., Studieson coumarins from the root of Angelica pubescens Maxim. IV. Structures of angelol-type prenylcoumarins. Chem. Pharm. Bull., 30, 2025-2035 (1982) https://doi.org/10.1248/cpb.30.2025
  2. Fujiwara, H., Yokoi, T., Tani, S., Saiki, Y. and Kato, .A., Studies on constituents of Angelica dahurica Radix I. On a new furocoumarin derivative. Yakugaku Zasshi, 100, 1258-1261 (1980) https://doi.org/10.1248/yakushi1947.100.12_1258
  3. Goodwin, H. R and Pollock, M. B., Ultraviolet absorption spectra of coumarin derivatives. Arch. Biochem. Biophys., 49, 1-6 (1954) https://doi.org/10.1016/0003-9861(54)90162-9
  4. Kim, C. M., Sin, M. K., Lee, K. S., and Ahn, D. K., The dictionary of Chinese medicines, Jungdam press, Seoul, pp. 2196-2205, 1998
  5. Kim, S. H., Kang S. S., and Kim, C. M., Coumarin glycosides from the roots of Angelica dahrinca. Arch. Pherm. Res., 15, 73-77 (1992) https://doi.org/10.1007/BF02973988
  6. Kozawa, M.,Matsuyama, Y., Fukumoto, M., and Baba, K., Chemical studies of Coelopleurum gmelinil (D. C.) LEDER I. Constituents of the roots. Chem. Pharm. Bull., 31, 64-69 (1983) https://doi.org/10.1248/cpb.31.64
  7. Kwon, Y. S., Kobayashi, A., Kajiyama, S. I., Kawazu, K., Kanzaki, H., and Kim, C. M., Antimicrobial constituents of Angelica dahurica roots. Phytochemistry, 44, 887-889 (1997) https://doi.org/10.1016/S0031-9422(96)00634-6
  8. Liu, J. H., Xu, S. X., Yao, X. S., and Kobayashi, H., Angelol-type coumarins from Angelica pubescence f. biserrata and their inhibitory effect on platelet aggregation. Phytochemistry, 39, 1099-1101 (1995) https://doi.org/10.1016/0031-9422(95)00045-9
  9. Pereda-Miranda, R., Hernandez, L., Villavicencio,M, J., Novelo, M., Ibarra, P., Chai, H., and Pezzuto, M. J., Structure and stereochemistry of pectinolides A-C, novel antimicrobial and cytotoxic 5, 6-dihydro-$\alpha$-pyronex from Hyptis pectinata. Journal of Natural Products, 56, 533-593 (1993)
  10. Steck W. and Mazurek, M., Identification of natural coumarins by nmr spectroscopy. Lloydia, 35, 418-439 (1972)
  11. Wu, T. S., Huang, S. C. and Lai, J. S., Stem bark coumarins of Citrus grandis. Phytochemistry, 36, 217-219 (1994) https://doi.org/10.1016/S0031-9422(00)97040-7