Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Effects of Opuntia ficus-indica var. Saboten Stem on Gastric Damages in Rats

  • Lee, Eun-Bang (National Products Research Institute, Seoul National University) ;
  • Hyun, Jin-Ee (National Products Research Institute, Seoul National University) ;
  • Li, Da-Wei (National Products Research Institute, Seoul National University) ;
  • Moon, Yung-In (Pukjeju Agricltural Development and Technology Extension Center)
  • Published : 2002.02.01
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Abstract

The effects of the dried stem powder of Opuntia ficus-indica var. saboten (OF-s) were investigated on gastric lesion and ulcer models in rats. It showed significant inhibition in HCl·ethanolinduced gastric lesion at the doses of 200 and 600 mg/kg p.o. and in HCl·aspirin-induced gastric lesion at 600 mg/kg p.o. OF-s also showed significant inhibition in indomethacin-induced gastric lesion at the doses of 200 and 600 mg/kg, p.o. However, it did not affect both the aspirin-induced and Shay ulcers in rats. It also did not affect gastric juice secretion, acid output and pH. These data indicate that OF-s only possesses pronounced inhibitory action on gastric lesion without antiulcer activity in rats.

Keywords

References

  1. Ahmad, A., Davides, J., Randall, S., and Skinner, G. R., Antiviral properties of extract of Opuntia streptacantha. Antiviral Res., 30, 75 (1996) https://doi.org/10.1016/0166-3542(95)00839-X
  2. Ahn, D. K., Illustrated book of Korean medicinal herbs, Kyohaksa, Seoul, pp.497, 1998
  3. Burret, F., Lebreton, P. H., and Voirin, B., Les aglycones flavoniques de cactees: distribution, signification. J. Nat. Pro., 45, 687-693 (1982) https://doi.org/10.1021/np50024a006
  4. Guth, P. H., Aures, D., and Paulsen, G., Topical Aspirin Plus HCI Gastric Lesions in the Rat. Gastroenterology, 76, 88 (1979)
  5. Galati, E. M., Monforte, M. T, Tripodo, M. M., d'Aquino, A. and Mondello, M. R., Antiulcer activity of Opuntia ficus-indica (L.) Mill. (Cactaceae): ultrastructural study. J. Ethnopharmacol., 76, 1-9 (2001) https://doi.org/10.1016/S0378-8741(01)00196-9
  6. Han, Y. N., Choo, Y. S., Lee, Y. C., Moon, Y. I., Kim, S. D., and Choi, J. W., Monoamine oxidase B inhibitors from the fruits of Opuntia ficus-indica var. saboten. Arch. Pharm. Res., 24, 51-54 (2001) https://doi.org/10.1007/BF02976493
  7. Ibanez-Camacho, R. and Roman-Ramos, R. Hypoglycemic effect of Opuntia cactus. Arch. Invest. Med. (Mex), 10, 223 (1979)
  8. Jeong, S. J., Jun, K. Y., Kang, T. H., and Ko, E. B. et al., Flavonoids from the fruits of Opuntia ficus-indica var. saboten. Kor. J. Pharmagn., 30, 84-86 (1999)
  9. Jiansu New College Medicine Eds. Encyclopedia of Chiness Herbs, Shanghai Science & Technology Publication, Shanghai, pp. 663 (1977)
  10. Lee, H. J., Korean flora, Moonkyobu Eds, Seoul, pp. 113, 1964
  11. Mizui, T. and Dodeuchi, M., Effect of polyamines on acidified ethanol induced gastric lesion in rats. Jpn. J. Pharmacol., 33, 939-945 (1983) https://doi.org/10.1254/jjp.33.939
  12. Okabe, S., Takeuchi, K., Nakamura, K., and Takagi, K., Pathogenesis of gastric lesion induced by aspirin in the pylorusligated rat. Jpn. J. Pharmacol., 24, 363 (1974) https://doi.org/10.1254/jjp.24.363
  13. Park, E. H., Kahng, J. H., and Paek, E. A., Stud es on the pharmacological actions of cactus: Identification of its anti-inflammatory effect. Arch. Pharm. Res., 21, 30 (1998) https://doi.org/10.1007/BF03216749
  14. Park, E. H., Kahng, J. H. Lee, S. H., and Shin, K. H., An anti-inflammatory principle from cactus. Fitotherapia, 72, 288-290 (2001) https://doi.org/10.1016/S0367-326X(00)00287-2
  15. Seiki, M., Ukei, S., Tanaka, Y., and Soeda, M., Studies of anti-ulcer effects of a new compound, zinc L-camosine (Z-103). Folia Pharmacol. Japan, 95, 257 (1990) https://doi.org/10.1254/fpj.95.5_257
  16. Shay, H., Komarov, S. A., Fels, S. S., and Meranze, D., A simple method for the uniform production of gastric ulceration in the rat. Gastroenterology, 4, 43-61 (1945)
  17. Suzuki, K., Araki, H., Komoike, Y., and Takeuchi, K., Permissive role of neutrophils in pathogenesis of indomethacin-induced gastric lesion in rats. Med. Sci. Monit.. 6, 908-914 (2000)
  18. Takagi, K., Takeuchi, K., Nakamura, K., Morita, A., and Okabe, S., Effects of an antiulcer agent, N-acetyl-L-glutamine aluminum complex (KW-110) on the duodenal and gastric ulcer models in the rat. Jpn. J. Pharmacol., 24, 357-361 (1974) https://doi.org/10.1254/jjp.24.357
  19. Takeuch, K. and Ueki, S., importance of gastric motility in the pathogenesis indomethacin-induced gastric lesion in rats. Dig. Dis. Sci., 31, 1114 (1986 https://doi.org/10.1007/BF01300266
  20. Yook, C. S., Saengyak Dogam, Gyoungwon Publ. Co., Seoul, pp. 351, 1996