Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
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Relationship among Body Composition, Biochemical Measurements and Serum Leptin Level in Obese Children

비만아의 체성분 및 생화학적 측정치와 혈중 Leptin 농도와의 관계

  • 최봉순 (대구가톨릭대학교 식품영양학과) ;
  • 손수진 (대구가톨릭대학교 식품영양학과) ;
  • 이희자 (경북대학교 식품영양학과) ;
  • 박명희 (대구대학교 식품영양학과) ;
  • 이은주 (대구가톨릭대학교 식품영양학과)
  • Published : 2002.05.01
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Abstract

The purpose of this study was to investigate the relationship among the anthropometric measurements, body composition indices, biochemical indices and serum leptin level of obese school children. The study was conducted on 97 elementary school children from 4-5th grade residing in Daegu and Kyungbuk area. Obesity was defined as fat percentage that exceed 25% of body fat mass. The prevalence of obesity of subject was 58.3% for male and 54.1% for female. The mean value of height, weight, body composition indices and biochemical indices of obese group were significantly higher than those of control group. The leptin level was significantly different in obese group but showed no difference by gender. The differences of leptin level were according to adiposity and BMI in obese subjects. Multiple regression analysis data showed that the BMI and body fat mass may influence on the leptin level of subject. Also, these data revealed the leptin resistance in obese children and relationship between leptin level and various factors including anthropometric measurements, body composition and biochemical indices. Additional research should be necessary to assess the mechanism of leptin resistance in obese children.

대구 및 대구 인근 경북지역 초등학교 4∼5학년에 재학 중인 남아 42명, 여아 55명을 대상으로 조사대상자들의 비만도에 따른 신체 계측치와 체성분 측정치, leptin를 비롯한 생화학적 자료들을 비교 분석하고, 이들 인자들간의 상호 관련성을 분석한 결과는 다음과 같다. 1) 여러 가지 방법으로 비만을 판정한 결과 체질량지수 25를 기준으로 하였을 때 비만군의 분포는 총 조사대상자의 30.9%, 상대체중 120%를 기준으로 하였을 때는 27.8%, 체지방을 25% 이상을 기준으로 했을 때는 56.7%로 나타났다. 체질량지수와 상대체중 상호간에는 높은 상관성 (r = 0.87, p <0.01)을 나타내었으나, 체지방율과는 중 정도의 상관성을 나타내었다 (r = 0.54, r = 0.59, p < 0.01). 2) 신체계측 및 체성분 분석 결과, 비만군이 대조군보다 신장, 체중 체지방량 제지방량, 근육량, 체지방을, 복부지방을, 체질량지수, 상완위 근육둘레가 남녀 모두 유의적으로 높게 나타났다 (p < 0.001). 특히 남아의 경우 비만군이 근육형태의 분포에서는 대조군과는 달리 저근육형 과체중의 분포가 매우 높게 나타났고, 신체발달점수도 유의하게 낮게 나타났다. 전체 조사대상자의 반 이상이 상하체 균형이 허약한 것으로 나타났다. 3) 혈액의 생화학적 검사 결과, 남아의 경우 HDL-cholesterol을 제외한 모든 측정치가, 여아의 경우 중성지방과 iron의 농도가 비만군이 대조군보다 유의적으로 높게 나타났다. 혈중 leptin농도는 남녀 모두 비만군이 대조군보다 유의적으로 높게 나타났으나, 성별에 따른 혈중 leptin농도는 유의적인 차이를 나타내지 않았다. 그러나 대조군에서는 여아가 남아보다 비만군에서는 오히려 남아가 여아보다 높은 경향을 보였다. 4) Leptin농도와 신체계측치 및 체성분 측정 치와의 관계에서 혈청 leptin함량은 측정된 모든 신체 계측치 및 체성분 분석치와 유의적인 높은 양의 상관관계를 나타냈다. 다변량분석 결과 전체대상자 중에서는 체질량지수가. 비만여부에 따라 분석하였을 때 대조군의 경우는 총지방량이 비만군의 경우는 체질량지수가 각각 독립적으로 leptin 농도에 실질적으로 예언력을 갖는 것으로 나타나 체지방 분포도에 따른 차이보다도 총체지방량 및 체질량지수와 관련이 더 있음을 보여주었다. 5) Leptin농도와 생화학적 지표와의 관련성을 분석한 결과, leptin 농도는 HDL-cholesterol를 제외한 측정된 모든 생화학적 지표와 유의적인 양의 상관관계를 나타내었다. 다변량분석 결과 전체대상자 중에서는 total-cholesterol, iron, 중성지방, ferritin의 농도가 각각 독립적으로 leptin 농도에 실질적인 예언력을 갖는 것으로 나타났고 비만 여부에 따라 분석하였을 때 비만군에서만 total-cholesterol, iron의 농도가 각각 독립적으로 leptin농도에 실질적인 예언력을 갖는 것으로 나타났다.

Keywords

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