Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
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Effects of Artemisia Capillaris Thunberg on the Plasma and Liver Lipid Metabolism in Rats

사철쑥 (Artemisia Capillaris Thunberg)이 흰쥐 혈액 및 간지질 대사에 미치는 영향

  • 이형자 (식품의약품안전청 식품평가부) ;
  • 황은희 (원광대학교 식품영양학과)
  • Published : 2002.05.01
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Abstract

This study was performed to investigate the influence of dietary and extract foods from A. capilliaris Thunberg on plasma and liver lipid metabolism in male Sprague-Dawley rats. For the experiment of liver and plasma lipid metabolism, Rats were find diets containing normal concentrations of fat or high concentrations of lard and two different preparations of A. capillaris Thunberg ; control diet (group C),50 mg/kg body weight A. capillary Thunberg methanol extract (group M), 6 g/kg diet A. capillary Thunberg dried powder (group P), high lard control diet (group L), 50 mg/kg body weight A. capillaris Thunberg with high lard (group LM) and 6 g/kg diet A. capillary Thunberg with hi\ulcorner lard (group LP). Effects of A. capillary Thunberg on plasma total cholesterol. High-density lipoprotein (HDL) cholesterol, Atherogenic index, triglyceride, plasma and liver peroxide contents, fatty acid composition of liver lipid and the distribution of fat droplets of liver. Supplementation of A. capillaris Thunberg resulted in lower plasma cholesterol, atherogenic index and triglyceride, and higher HDL-cholesterol in rats find high lard diets. However, these effects were not observed with low level of fat (groups C, M and P). A shift caused by feeding high lard diets in increased plasma and liver peroxides, saturated fatty arid composition of liver lipid and the more frequent distribution of fat droplets in liver could be reversed by feeding A. capillary Thunberg. This study suggests that A. capillary Thunberg co alter lipid metabolism in plasma and liver.

사철쑥 (Artemisia capitlaris Thunberg)으로 성인병의 예방목적으로 흰쥐 (Sprague-Dawley rats)의 혈액 및 간지질 대사에 미치는 영향에 대한 효과를 알아보았다. 1) 사료이용효율은 L, LM, LP군에서 높았다 (p < 0.01). 혈청의 콜레스테롤 농도, 동 맥 경화지수 (p <0.01), 중성지질 (p < 0.01)은 L, LM, LP군에서 높았지만, 사철쑥 분말 첨가에 의해 HDL-콜레스테롤과 HTR를 증가시켰다 (p < 0.01). 2) 혈청 및 간 조직의 과산화지질은 C군에 비하여 L군이 유의적으로 많았으며, 사철쑥 첨가시 감소하였다 (p < 0.05). 3) 간 조직의 지방침착은 L군에서 지방양성구의 크기와 분포가 두드러지게 높았고. LM군, LP길군에서는 감소하였다. 이상의 결과는 사철쑥은 혈액 및 간의 지질조성 및 지질 대사에 바람직한 효과를 갖는 것으로 보인다. 이는 사철쑥이 성인병예방에 유용한 기능성 식품으로서 가치가 있을 것으로 사료된다.

Keywords

References

  1. Journal of Korean Association of Cancer Prevention v.3 The rold of alternative medicine for the treatment of cancer Kim N.D.;Lim Y.H.
  2. Introduction to risk factors in coronart artery disease in medical communication Stamler J.
  3. Proc. Nutr Soc. v.43 Microbal digestion of complex carbohydrates in man Cummings J.H. https://doi.org/10.1079/PNS19840025
  4. Ann Rev Nutr v.8 Dietary fiber Kritchevsky D. https://doi.org/10.1146/annurev.nu.08.070188.001505
  5. Yearbook of health and welfare statistics v.4 no.5 Ministry of Health and Welfare Republic of Korea
  6. Effects of artemisia capillaris on liver lipid metabolism in rats and apoptosis in HeLa cells Lee H.J.
  7. Studies on the Biological activities artemisia Rim S.N.
  8. Korean J. Nutr v.30 no.6 Biological activity of the soluble extracts from artemisia princeps var orientalis acted on cardiovascula system Rim SS;Lee JH
  9. Korean J. Nutr v.30 no.1 Effect of artemisia princeps var orientalis and circium japonicum var ussuriense on serum lipid of hyperlipidemic rat Lim S.S.;Lee J.H.
  10. J. Korean Soc. Food Sci. Nutr. v.27 no.2 Effects of artemisia capillaris kitamura ethanol extract on lowering serum and liver lipids in rats Nam S.M.;Ham S.S.;Oh D.H.;Kang I.J.;Lee S.Y.;Chung C.K.
  11. Korean J. Vet. Res. v.32 no.3 Effect of artemisia iwayomogi water extract on hepatic injury by carbon tetrachloride in rats I. Effect on serum AST, ALT, LDH activities, lipid conte nt and liver peroxide content Kim KS;Park JH
  12. J. Korean Soc. Food Sci. Nutr v.28 no.1 Effects of artemisia iwayomogi extracts on antioxidant enzymes in rats administered benzo(α)pyrene Nam SM;Kim JG;Ham SS;Kim SJ;Chung ME;Chung CK
  13. Am. J. Chin Med v.15 no.3-4 Evaluation of artemisia inculta for anti-inflammatory activity in rats Tariq MM;Mossa JS;Al-Yahya MA;Parmar NS;Ageel AM https://doi.org/10.1142/S0192415X87000163
  14. J. Ethnopharmacol v.43 no.3 Hypoglycemic activity of artemisia herba alba Twaij HA;Al-Badr AA https://doi.org/10.1016/0378-8741(94)90038-8
  15. Korean J. Biotechnol Bioeng v.9 no.5 Antimicrobial activity of extracts and coumaric acid isolated from artemisia princeps var. orientalis Park SK;Park JC
  16. Korean J. Food Sci. Technol v.24 no.1 Studies on the nutritional components of mugwort artemisia mongolica fisher Sim YJ;Han YS;Chun HJ
  17. Korean J. Food & Nutr. v.13 no.5 Bioactive constituents and utilities of artemisia sp. as medicinal herb and foodstuff Lee SD;Park HH;Kim DW;Bang HB
  18. Studies on the herb that make practical application of foods Ahn JM
  19. Korean resources plants Ⅳ Kim TJ
  20. Allelopathic effects of essential oils of some plant species in artemisia on selected plants and microbes Yoo HG
  21. Amino acid analysis and effect of artemisia sp. in rat blood Kim SM
  22. Yakhak Hoeji v.43 no.4 Characterization of polysaccharides from artemisia capillaris and artemisia sylvatica Hwang EJ;Kwon HC;Jung CM;Moon HI;Kim SY;Zee OP;Lee KR
  23. J. Korean Soc. Food Sci. Nutr. v.27 no.2 Effects of scoparone on liver function Cho MK;Choe SY;Hong SM;Kim BS
  24. Kor. J. Pharmacogn v.23 no.2 The effect of scoparone on the hepatic bromobenzene metabolizing enzyme system in rats Kim EJ;Lee CK;Choi JW
  25. National Research Council(NRC)
  26. J. Nutr. v.119 AIN-76 diet should we change the formulation Reeves PG
  27. J. Korean Soc. Food Nutr v.14 no.2 A study on the nutritional effects in rats by feeding basal diet supplemented with mugwort powder Haw IW;Lee SD;Hwang WI
  28. Korean J. Nutrition v.30 no.5 Effects of alginic acid cellulose and pectin level on bowel function in rats Lee HJ;Hwang EH
  29. Korean J. Nutrition v.30 no.8 Effects of mugwort dried orange peel and duchung on lipid metabolism in hyperlipidemia rats Kim JH;Wang SG
  30. Jouranl of Medical Technology v.20 no.9 Iwata I.
  31. Lipid peroxidation in biology and medicine Yagi K.
  32. Theory and practice of histotechnology Denzac Sheehan;Barbara B. Hrapchak
  33. J. Nutr v.115 Effect of dietary polyunsaturated/saturated fatty acid ratio and dietary vitamin E on lipid peroxidation in the rat Buckingham KW
  34. J. Biol Chem v.226 A simple method for isolation and purification of total lipids from animal tissues Folch J;Lees M;Sloand-stanley GH
  35. J. Lipid Res v.5 Preparation fatty acid ethyl esters and dimethylacetals from lipids with boron fluoride-methanol Morrison WR;Smith LM
  36. J. Korean Soc. Food Nutr. v.14 no.2 A study on the nutritional effects in rats by feeding basal diet supplemented with mugwort powder Haw IW;Lee SD;Hwang WI
  37. Korean J. Food & Nutr v.13 no.5 Effects of feeding basal diet supplemented with mugwort powder on the serum components in rat Lee SD;Park HH
  38. Korean J. Community Nutr v.2 Effects of green tea infusion on the preneoplastic lesions and peroxidation in rat hepatocarcinogenesis Kim HS;Kim HS;Choi H.
  39. J. Korean Soc. Food Nut. v.24 The chemical composition of persimmon (Diospyros Kaki, Thumb) leaf tea Joung SY;Lee SJ;Sung NJ;Jo JS;Kang SK
  40. The Korean Nutrition Society Oil seeds refining & oil consumption pattern Kim SH
  41. Experientia v.34 Hypotensive activity of some dihydroxycoumarins and their congeners Thakur RS;Bagadia SC;Sharma ML https://doi.org/10.1007/BF01944649
  42. Studies of scoparone on the detoxication mechanism in mice, Ph D Thesis Park JM
  43. Yakagaku Zasshi v.102 Biochemical evaluation of artemisia capillaris flos Yamahara J;Matsuda H;Sawada T;Mibu H;Fujimura H
  44. Am J. Clin Nutr. v.53 Dietary fats and cancer Kenneth KC
  45. Chem Pharm Butl v.33 no.5 Studies on the activities of tannins and related compounds from medicinal plants and drugs. Ⅶ Effects of extracts of leaves of artemisia species and caffeic acid and chlorogenic acid on lipid metabolic injury in rats fed peroxidized oil Kimura Y;Okuda H;Okuda T;Hatano T;Agata I;Arichi S https://doi.org/10.1248/cpb.33.2028
  46. J. Korean Soc. Food Sci. Nutr. v.25 no.4 Effects of artemisia selengensis methanol extract on ethanol-induced hepatotoxicity in rat liver Kim KS;Lee MY
  47. Panereas v.17 no.2 Induction of apoptosis with an extract of artemisia asiatica attenuates the severity of cerulein-induced pancreatitis in rats Hahm KB;Kim JH;You BM;Kim YS;Cho SW;Yim H;Ahn BO;KIm WB
  48. J. Korean Soc. Food Sci. Nutr. v.21 Effect of acanthopanacis cortex boiling extract solutions on fat accumulation in the obese rats induced by high fat dietary Sung TS;Son GM;Bae MJ;Choi C
  49. Korean J. Ginseng Sci. v.10 no.167 Effect of ginseng on fat accumulation in the obese rats induced by high fat diet Kim SI;Kim YS;Jeon BS;Lim C