Journal of Nutrition and Health

  • 제35권1호
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  • Pages.53-59
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  • 2002
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  • 2288-3886(pISSN)
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  • 2288-3959(eISSN)
한국영양학회 (The Korean Nutrition Society)
권호 표지

녹차의 (-)EGCG에 의한 사람 폐암 세포주 A549의 c-Jun N-terminal Kinase 1과 Activating Protein-1활성화를 통한 세포고사

Green Tea (-)EGCG Induces the Apoptotic Death of Lung Cancer Cells via Activation of c-Jun N-terminal Kinase 1 and Activating Protein-1

  • 박지선 (전북대학교 식품영양학과) ;
  • 신미경 (원광대학교 식품영양학과) ;
  • 손희숙 (전북대학교 식품영양학과) ;
  • 박래길 (원광대학교 의과대학 미생물학교실) ;
  • 김명선 (원광대학교 의과대학 미생물학교실) ;
  • 정원훈 (원광보건대학)
  • 발행 : 2002.01.01
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초록

Green tea has been recognized as a favorite beverage for centuries in Easter and Westers cultures. Recently, anti-tumor effects of green tea constituents have received increasing attention. However, the mechanism of catechin-mediated cytotoxicity against tumor cells remains to be elusive. To elucidate the mechanical insights of anti-tumor effects, (-)epigallocatechin-gallate(EGCG) of catechin was applied to human lung cancer A549 cells. (-)EGCG induced the death of A549 cells, which was revealed as apoptosis in DNA fragmentation assay. (-)EGCG induced the activation of caspase family cysteine proteases including capase-3, -8 and -9 proteases in A549 cells. Furthermore, (-)EGCG increased the phosphotransferase activity of c-Jun N-terminal kinase 1JNK 1), which further induced tole transcriptional activation of activating protein-1(AP-1) in A549 cells. We suggest that (-)EGCG-induced apotosis of A549 cells is mediated by signaling pathway involving caspase family cysteine protease, JNK1 and transcription factor, AP-1.

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참고문헌

  1. J Nutr Sci Vitaminol v.32 no.6 Effect of green tea catechins on ploasma cholesterol level in cholesterol-fed rats Muramatsu K;Fukuyo M;Hara Y https://doi.org/10.3177/jnsv.32.613
  2. Nature v.398 no.6726 Angiogenesis inhibited by drinking tea Cao Y;Cao R https://doi.org/10.1038/18793
  3. Agric Biol Chem v.55 no.7 Antibacterial activity of tea polyphenols against phytopathogenic bacteria Fukai K;Ishigami T;Hara Y https://doi.org/10.1271/bbb1961.55.1895
  4. Nippon Shokuhin Kogyo Gakkaishi v.38 no.3 Platelet aggregation inhibitory activity of tea extracts Namiki K;Yamanaka M;Tateyama C;Igarashi M;Namiki M https://doi.org/10.3136/nskkk1962.38.189
  5. 日本營養·食糧學會誌 v.43 no.5 Hypotensive effect of tea catechins on blood pressure of rats Hara Y;Tono-Oka F
  6. Biosci Biotech Biochem v.57 no.4 Reduction of blood glucose levels by tea catechin Matsumoto N;Ishigaki F;Ishigaki A;Iwashina H;Hara Y https://doi.org/10.1271/bbb.57.525
  7. Cancer Lett v.116 no.1 Post-initiation inhibitory effects of green tea catechins on 7, 12-dimethylbenz[a]anthracene-induced mammary gland carcinogenesis in female sprague-Dawley rats Tanaka H;Hirose M;Kawabe M;Sano M;Takesada Y;Hagiwara A;Shirai T https://doi.org/10.1016/S0304-3835(97)04749-6
  8. Anticancer Res v.16 Induction of programmed cell death(apoptosis) in human leukemia cells by catechins compounds Hibasami H;Achiwa Y;Fujikawa T;Komiya T
  9. Prev Med v.26 Cancer-preventive effects of drinking tea among a japanese population Imai K;Suga K;Nakachi K https://doi.org/10.1006/pmed.1997.0242
  10. Life Sci v.60 no.2 Effect of (-)-epigallocatechin gallate on leukemic blast cells from patients with acute myeloblastic leukemia Asano Y;Okamura S;Ogo T;Eto T;Otsuka T;Niho Y https://doi.org/10.1016/S0024-3205(96)00603-0
  11. Oncol Rep v.5 no.2 Induction of apoptosis in human stomach cancer cells by green tea catechins Hibasami H;Komiya T;Achiwa Y;Ohnishi K;Kojima T;Nakanishi K;Akashi K;Hara Y
  12. Cancer Lett v.130 no.1-2 Induction of apoptosis in prostate cancer cell lines by the green tea component, (-)-epigallocatechin-3-gallate Paschka AG;Butler R;Young CY https://doi.org/10.1016/S0304-3835(98)00084-6
  13. Nature v.387 no.6633 Why drinking green tea could prevent cancer Jankun J;Selman SH;Swiencz R;Skrzypczak-Jankun E https://doi.org/10.1038/42381
  14. Mol Biol Cell v.10 no.4 Epigallocathechin-3 gallate selectively inhibits the PDGF-BB-induced intracellular signaling transduction pathway in vascular smooth muscle cells and inhibits transformation of sistransfected NIH 3T3 fibroblasts and human glioblastoma cells(A172) Ahn HY;Hadizadeh KR;Seul C;Yun YP;Vetter H;Sachinidis A https://doi.org/10.1091/mbc.10.4.1093
  15. Mutat Res v.402 no.1-2 Cancer inhibition by green tea Fujiki H;Suganuma M;Okabe S;Sueoka N;Komori A;Sueoka E;Kozu T;Tada Y;Suga K;Imai K;Nakachi K https://doi.org/10.1016/S0027-5107(97)00310-2
  16. J Cell Biochem no.SUP.22 Polyphenols as cancer chemopreventive agents Stoner GD;Mukhtar H
  17. Br J Cancer v.84 no.6 EGCG, a major component of green tea, inhibits tumour growth by inhibiting VEGF induction in human colon carcinoma cells Jung YD;Kim MS;Shin BA;Chay KO;Ahn BW;Liu W;Bucana CD;Gallick GE;Ellis LM
  18. J natl Concer Inst v.89 no.24 Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells Ahmad N;Feyes DK;Nieminen AL;Agarwal R;Mukgtar H
  19. Biochem Biophys Res Commun v.275 no.2 Cell cycle dysregulation by green tea polyphenol epigallocatechin-3-gallate Ahmad N;Cheng P;Mukhtar H https://doi.org/10.1006/bbrc.2000.3297
  20. Science v.262 Programmed cell death and the control of cell survival Raff MC;Bares BA;Burne JF;Coles HS;Ishizaki Y;Jacobson MD https://doi.org/10.1126/science.8235590
  21. J Patho v.173 Apoptosis in the immune system Williams GT https://doi.org/10.1002/path.1711730102
  22. Cell v.65 Programmed cell death:apoptosis and oncogenesis Williams GT https://doi.org/10.1016/0092-8674(91)90002-G
  23. Science v.267 Apoptosis in the pathogenesis and treatment of disease Thomson CB https://doi.org/10.1126/science.7878464
  24. Adv Pharmacol v.41 Chemotherapy-induced apoptisis Mesner PW Jr;Budihardjo Ⅱ;kaufmann SH https://doi.org/10.1016/S1054-3589(08)61069-8
  25. Surgery v.130 no.2 NF-kapa B-mediated chemoresistance in breast cancer cells Weldon CB;Burow ME;Rlofe KW;Clayton JL;Jaffe BM;Beckman BS https://doi.org/10.1067/msy.2001.115512
  26. Gynecol Oncol v.83 no.2 Bax-induced apoptosis as a nover gene therapy approach for carcinoma of the cervix Huh WK;Gomez-Navarro J;Arafat WO;Xiang J;Mahasreshti PJ;Alvarez RD;Barnes MN;Curiel DT https://doi.org/10.1006/gyno.2001.6403
  27. Gen Pharmacol v.34 no.5 Activation of caspase cascades in Korean mistletoe(Viscum album var. coloratum) lectin-Ⅱ-induced apoptosis of human myeloeukemic U 937 cells Kim MS;So HS;Lee KM;Park JS;Lee JH;Moon SK;Ryu DG;Chung SY;Jung BH;Kim YK;Moon G;Park R https://doi.org/10.1016/S0306-3623(01)00072-6
  28. Biochemical Pharmacol v.61 no.7 Protective effects of morphine in peroxynitrite-induced apoptosis of primary rat neonatol astrocytes:potential involvement of G protein and phosphatidylinositol 3-ki-nase(PI 3-kinase) Kim MS;Cheong YP;So HS;Lee KM;Kim TY;Oh J;Chung YT;Son Y;Kim BR;Park R https://doi.org/10.1016/S0006-2952(01)00541-X
  29. Eur J Biochem v.254 Apoptosis signal by death receptors Klaus SO;Davide F https://doi.org/10.1046/j.1432-1327.1998.2540439.x
  30. J Biol Chem v.273 Dopamine induces apoptosis through an oxidation-involved SAPK/JNK activation pathways Luo Y;Umegaki H;Wang X;Abe R;Roth GS https://doi.org/10.1074/jbc.273.6.3756
  31. Adv Exp Med Biol v.493 Opiates promote Tcell apoptosis through JNK and caspase pathway Singhal P;Kapasi A;Reddy K;Franki N
  32. J Radiat Res v.42 no.2 Fas-independent apoptosis induced by UVC in p53-mutated human epithelial tumor A431 cells through activation of caspase-8 and JNK/SAPK Hama-Inaba H;Choi KG;Wang B;Haginoya K;Yamada T;Hayata I;Ohyama H https://doi.org/10.1269/jrr.42.201
  33. Nature v.380 Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis Verheij M;Bose R;Lin;Yao B;Jarvis W;Grant S;Birrer M;Szabo E;Zon L;Kyriakis J;Haimovitz-Friedman A;Fuks Z;Kolensnick R https://doi.org/10.1038/380075a0
  34. Eur J Immunol v.26 Wilson DJ;Fortner KA;Lynch DH;Mattingly RR;Macara IG;Posada JA;Budd RC https://doi.org/10.1002/eji.1830260505
  35. EMBO v.16 A novel SAPK/JNK kinase, MKK7,stimulated by TNF-α and cellular stresses Moriguchi T;Toyoshima F;Masuyama N;Hanafusa H;Gotoh Y; Nishida E https://doi.org/10.1093/emboj/16.23.7045
  36. Hosp Pract(Off Ed) v.28 no.12 Apoptosis:the physiologic pathway of cell death Cohen JJ
  37. Proc Natl Acad Sci USA v.92 no.15 Preferential expansion and survival of B lymphocytes based on VH framework 1 and framework 3 expression:"positive" selection in apendix of normal and VH-mutant rabbits Pospisil R;Young-Cooper GO;Mage RG https://doi.org/10.1073/pnas.92.15.6961
  38. Cell v.86 no.2 Size control:the regulation of cell numbers in animal development Raff MC https://doi.org/10.1016/S0092-8674(00)80087-2
  39. J Biol Chem v.273 no.50 Caenorhabditis elegans EGL-1 disrupts the interaction of CED-9 with CED-4 and promotes CED-3 activation Del Peso L;Gonzalez VM;Nunez G https://doi.org/10.1074/jbc.273.50.33495
  40. Trends Biochem Sci v.16 MAPKs:new JNK expands the group Davis RJ
  41. Nature v.369 no.6476 The stress-activated protein kinase subfamily of c-Jun kinases Kyriakis JM;Baverjee P;Nikolakaki E;Dai P;Rubie EA;Ahmad MF;Avruch J;Woodgett JR https://doi.org/10.1038/369156a0
  42. J Biol Chem v.271 no.48 Role of the stress-activated/c-Jun NH2-terminal protein kinase pathway in the cellular response to adriamycin and other chemotherapeutic drugs Osborn MT;Chambers TC https://doi.org/10.1074/jbc.271.48.30950
  43. Genes Dev v.7 Identification of an oncoprotein-and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain Hibi M;Lin A;Smeal T;Minden A;Karin M https://doi.org/10.1101/gad.7.11.2135
  44. Biochem Soc Symp v.64 Signaling transduction by the c-Jun N-terminal kinase Davis RJ