Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Effect of 1% Garlic Powder on Serum and Liver Lipid and Plasma Amino Acid Concentration in Rats Fed Cholesterol Diet

고콜레스테롤 식이 섭취시 1%마늘가루 첨가가 혈액 및 간조직 중 지질과 혈중 유리 아미노산 농도에 미치는 영향

  • 조현주 (계명대학교 식품영양학과) ;
  • 최미자 (계명대학교 식품영양학과)
  • Published : 2002.02.01
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Abstract

The serum lipid-lowering effect of garlic was examined in hypercholesterolemic rats. The food intake was not significantly different by garlic powder supplementation. The inclusion of 1% garlic powder in a diets containing 1% cholesterol brought a reduction in the serum cholesterol and triglyceride. Liver lipids were not affected by the addition of l% garlic Powder in hypercholesterolemic rats. Earlier studies have suggested that the effect of garlic on serum cholesterol may be related to the sulfur-containing amino acids of products released during protein digestion. However, our results in rats fed garlic powder diet showed no specific effect on plasma free amino acid concentrations. In conclusion. this study clears shows that garlic intake is able to reduce the levels of serum cholesterol in hypercholesteroolemic rats. However, further studies have to be done in order to elucidate the mechanism underlying this phenomenon.

본 실험의 결과를 요약해 보면, 체중증가량, 체중 증가 패턴, 식이섭취량, 식이효율은 대조군과 마늘군 사이에 유의적 차이가 없는 것으로 나타났으며, 혈중 포도당 농도는 마늘 첨가군에서 다소 낮은 경향이었으나 유의적 차이는 나타나지 않았다. 혈중 중성지방과 총콜레스테롤, LDL-콜레스테롤 농도는 마늘군이 대조군보다 유의적으로 낮게 나타내지 않았고, atherogenic index역시 유의적 차이는 나타나지 않았다. 간조직 중 중성지방과 총콜레스테롤 농도는 대조군과 마늘군 간의 유의적 차이가 나타나지 않았으며 혈중 유리아미노산의 농도 역시 대조군과 마늘군 사이의 유의적 차이가 없는 것으로 나타났다. 이상과 같이 고콜레스테롤 식이 섭취시 1% 수준의 마늘가루 첨가는 간조직 중 지질농도에는 영향을 미치지 않는 것으로 나타났으나, 혈장 총콜레스테롤과 중성지질을 유의적 낮추었으므로 식이 중 마늘의 섭취는 고지혈증의 개선에 유익한 효과를 가질 것으로 기대된다. 마늘이 체내 유리아미노산 농도에 미치는 영향에 대해서는 아직 단정지을 수 없으며 앞으로 더 많은 연구가 필요할 것으로 사료된다.

Keywords

References

  1. 경제기획원 조사 통계국 : 1995년 사망원인의 통계연보 (1995)
  2. Keys, A. : Coronary heart disease in seven countries. Circulation, 41, 201-211 (1970)
  3. Hopkins, P.N. and Willianms, R.R.A. : Survey of 246 suggested coronary risk factors. Atherosclerosis, 40, 1-52 (1981) https://doi.org/10.1016/0021-9150(81)90122-2
  4. National Institutes of Health : Lowering blood cholesterol to prevent heart disease. J. Am. Med. Assoc., 253, 2080-2092 (1985) https://doi.org/10.1001/jama.253.14.2080
  5. Lim, S.S. and Lee, J.H. : Effect of Artemisia Princeps var Orientalis and Ccircium japonicum var ussuriense on serum lipid of hyperlipidemic rat. Korean J. Nutr., 30, 12-18 (1997)
  6. Gang, M.S., Lim, S.S. and Lee, J.H. : A study on the chemical composition and hypocholesterolemic effect of nostoc commune. J. Korean Soc. Food Sci. Nutr., 26, 468-472 (1997)
  7. Sung, I.S., Kim, M.J. and Cho, S.Y. : Effect of quercus acutissima carruthers extracts on the lipid metabolism. J. Korean Soc. Food Sci. Nutr., 26, 327-331 (1997)
  8. Kang, J.A. and Kang, J.S. : Effect of garlic and onion on plasma and liver cholesterol and triglyceride and platelet aggregation in rats fed basal or cholesterol supplemented diets. Korean J. Nutr., 30, 132-138 (1997)
  9. 김정숙 : 한국인의 지방섭취와 고지혈증에 관한 연구. 안양전문대학논문집, 20, 341-352 (1997)
  10. Chun, H.J. and Paik, J.E. : Effect of heart treatment of garlic added diet on the blood of spontaneously hypertention rat. J. Korean Soc. Food Sci. Nutr., 26, 103-108 (1997)1111
  11. Bordia, A. and Bansal, H.C. : Essential oil of garlic in prevention of atherosclerosis. Lancet, 2, 1491-1492 (1973)1111
  12. Warshafsky, S., Kamer, R.S. and Sivak, S.L. : Effect of garlic on total serum cholesterol. Ann. Intern. Med., 119, 599-605 (1993) https://doi.org/10.7326/0003-4819-119-7_Part_1-199310010-00009
  13. Augusti, K.T. : Hypocholesterolemic effect of garlic (Allium sativum Linn). Ind. J. Exp. Biol., 15, 489-490 (1997)
  14. Kendler, B.S. : Garlic (Allium sativum) and onion (Allium cepa) : A review of their relationship to cardiovascular disease. Prev Med., 16, 670-685 (1987) https://doi.org/10.1016/0091-7435(87)90050-8
  15. Srivastava, K.C., Bordia, A. and Verma, S.K. : Garlic (Allium sativum) for disease prevention. South African J. Sci., 91, 68-77 (1995)
  16. Boulain, D.J. : Garlic as a platelet inhibitor. Lancet, 1, 776-777 (1981)
  17. Harenberg, J., Giese, C. and Zimmerman, R. : Effect of dried garlic on blood coagulation, fibrinolysis, platelet aggregation and serum cholesterol levels in patients with hyperlipoproteinemea. Atherosclerosis, 74, 247-249 (1988) https://doi.org/10.1016/0021-9150(88)90244-4
  18. Kiesewetter, H., Jung, F., Jung, E.M. and Wemzel, E. : Effect of garlic on platelet aggregation onpatients with increased risk of juvenile ischaemic attack. Eur. J. Clin. Pharmacol., 45, 333-336 (1993)
  19. Jain, M.K. and Apitz-Castro, R. : Garlic : A product of spilled ambrosia. Curr. Sci., 65, 148-156 (1993)
  20. Block, E., Naganathan, S. and Putman, D. : Garlic and onion chemistry. Chem. Int., 65, 625-632 (1993)
  21. Melling, W.C. and Johnson, M.A. : Effect of garlic on carbohydrate metabolism and lipid synthesis in rats. J. Nutr., 110, 931-936 (1980) https://doi.org/10.1093/jn/110.5.931
  22. Oi, Y., Kawada, T., Kitamura, K., Oyama, F., Nitta, N., Kominato, Y., Nishimura, S., Kazuo and Iwai, K. : Garlic supplementation enhances norepinephrine secretion, growth of brown adipose tissue, and triglyceride catabolism in rats. J. Nutr. Biochem., 6, 250-255 (1995) https://doi.org/10.1016/0955-2863(95)00025-U
  23. Folch, J. and Lees, M. : Sloanestanley G.H. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem., 226, 497-509 (1957)
  24. Friedewald, W.T., Levy, R.J. and Fredrickson, D.S. : Estimation of concentration of low density lipoprotein cholesterol in plasma without use of ultracentrifuge. Clin. Chem., 18, 499-502 (1972)
  25. Bordia, A. : Effect of garlic on blood lipids in patients with coronary heart disease. Am. J. Clin. Nutr., 34, 2100-2103 (1981) https://doi.org/10.1093/ajcn/34.10.2100
  26. Ernst, E., Welhmayr, T.H. and Matrai, A. : Garlic and blood lipids. Brit. Med. J., 291, 139-152 (1985)
  27. Jain, R.C. : Effect of garlic on serum lipids, coagulability and fibrinolytic activity. Am. J. Clin. Nutr., 30, 1380-1381 (1977) https://doi.org/10.1093/ajcn/30.9.1380
  28. Phelps, S. and Harris, W.S. : Garlic supplementation and lipoprotein oxidation susceptibility. Lipid, 28, 475-477 (1993) https://doi.org/10.1007/BF02535949
  29. Arora, R.C. and Arora, S. : Comparative effects of clofibrate, garlic, and onion on alimentary hyperlipidemia. Atherosclerosis, 39, 447-452 (1981) https://doi.org/10.1016/0021-9150(81)90002-2
  30. Arora, R.C., Arora, S. and Nigam, P. : Rationale of garlic use in ischemic heart disease. Mater Med. Pol., 17, 48-50 (1985)
  31. Luley, C., Moller, B., Martin, T. and Schwartzkopff, W. : Lack of efficacy of dried garlic in patients with hyperlipoproteinemia. Arzneim Forsch., 36, 766-768 (1986)
  32. Lau, B.H.S., Adetumbi, M.A. and Sanchez, A. : Allium sativum (garlic) and atherosclerosis (A review). Nutritation Research, 3, 119-128 (1983) https://doi.org/10.1016/S0271-5317(83)80128-6
  33. Bordia, A., Verma, S.K., Vyas, V.K., Khabya, B.L., Rathore, A.S., Bhu, N. and Bedi, H.K. : Effect of essential oil of onion and garlic on experimental atherosclerosis in rabbits. Atherosclerosis, 26, 379-386 (1977) https://doi.org/10.1016/0021-9150(77)90092-2
  34. Choi, M.S., Koh, E.T. and Stewart, T.J. : Effects of garlic on lipid metabolism in rats fed cholesterol or lard. J. Nutr., 112, 241-248 (1982) https://doi.org/10.1093/jn/112.2.241
  35. Sautier, C., Dieng, K., Flament, C., Doucet, C., Suquet, J. P. and Lemonnier, D. : Effects of whey protein, casein, soyabean and sunflower proteins on the serum, tissue and faecal steroids in rats. Br. J. Nutr., 49, 313-319 (1983) https://doi.org/10.1079/BJN19830040
  36. Sugiyama, K., Ohkawa, S. and Muramatsu, K. : Effect of methionine, cystine and taurine on plasma cholesterol level in rats fed a high cholesterol diet. Agric. Biol. Chem., 48, 2897-2899 (1984) https://doi.org/10.1271/bbb1961.48.2897
  37. Sugiyama, K., Ohkawa, S. and Muramatsu, K. : Effect of methionine, cystine and taurine on plasma cholesterol level in rats fed a high cholesterol diet. Agric. Biol. Chem., 48, 2897-2899 (1984) https://doi.org/10.3177/jnsv.32.413

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