The Journal of Korean Physical Therapy

The Korean Society of Physical Therapy (대한물리치료학회)
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Effects of GaAIAs Diode Laser for the Expression of TGF-$\beta$ on Lumbar Spinal Cord after Extensor Digitorum Muscle Crush Injury

GaAlAs 다이오드 레이저 조사가 장지신근 압좌손상 후 요수분절의 TGF-$\beta$ 발현에 미치는 영향

  • Kim Souk-Boum (Major in Physical Therapy, Dept. of Rehabilitation Science, Graduate School, Taegu University) ;
  • Nam Ki-Won (Major in Physical Therapy, Dept. of Rehabilitation Science, Graduate School, Taegu University) ;
  • Koo Hyun-mo (Major in Physical Therapy, Dept. of Rehabilitation Science, Graduate School, Taegu University) ;
  • Lee Sun-Min (Major in Physical Therapy, Dept. of Rehabilitation Science, Graduate School, Taegu University) ;
  • Kim Jin-Sang (Department of Physical Therapy, College of Rehabilitation Science, Taege University)
  • 김석범 (대구대학교대학원 재활과학과 물리치료) ;
  • 남기원 (대구대학교대학원 재활과학과 물리치료) ;
  • 구현모 (대구대학교대학원 재활과학과 물리치료) ;
  • 이선민 (대구대학교대학원 재활과학과 물리치료) ;
  • 김진상 (대구대학교 재활과학대학 물리치료학과)
  • Published : 2002.12.01
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Abstract

Low intensity laser irradiation is potential physical agent that triggers the muscle regeneration by previous study. In muscle regeneration, a number of growth factors also promotes that is triggered in response to muscle damage. The transforming growth factor(TGF)-$\beta$ is involved in the activation of cell proliferation and the inhibition of cell differentiation in muscle regeneration. This is secreted not only autocrine system but also paracrine and endocrine. Therefore, We investigated that effects of Gallium aluminum arsenide(GaAlAs) diode laser for the expression of TGF-$\beta$ on lumbar spinal cord after extensor digitorum muscle crush injury. After laser irradiation, the immunoreactivity of TGF-$\beta$ was increased bilaterally in gray mater of spinal cord. Especially, in 1 day, experimental group was highed than control, and in 3 day, lateral motor nucleus were storong immunoreactivy of TGF-$\beta$. Also, in 1 and 2 day, TGF-$\beta$ was showed in white mater as well as gray mater, but in 3 day, only showed in gray mater. These data may suggests to the establishment of laser irradiation on spinal cord for skeletal muscle injury.

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