The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Effects of Yukmijihwang-tang to Recover the Brain Damage of Mice

육미지황탕이 흰쥐의 뇌손상 회복에 미치는 영향

  • Kim, Bang-Oul (Dept. of Internal Medicine, College of Oriental Medicine Dongshin University) ;
  • Kim, Kyoung-Sun (Dept. of Internal Medicine, College of Oriental Medicine Dongshin University) ;
  • Jeon, Hong-Yeol (Dept. of Internal Medicine, College of Oriental Medicine Dongshin University) ;
  • Kang, Hwa-Jeong (Dept. of Internal Medicine, College of Oriental Medicine Dongshin University) ;
  • Kim, Jeong-Sang (Dept. of Anatomy, College of Oriental Medicine Dongshin University) ;
  • Hong, Seok (Dept. of Internal Medicine, College of Oriental Medicine Dongshin University) ;
  • Kim, Yong-Jin (Dept. of Internal Medicine, College of Oriental Medicine Dongshin University)
  • 김방울 (동신대학교 한의과대학 심계내과학교실) ;
  • 김경선 (동신대학교 한의과대학 심계내과학교실) ;
  • 전홍열 (동신대학교 한의과대학 심계내과학교실) ;
  • 강화정 (동신대학교 한의과대학 심계내과학교실) ;
  • 김정상 (동신대학교 한의과대학 해부학교실) ;
  • 홍석 (동신대학교 한의과대학 심계내과학교실) ;
  • 김용진 (동신대학교 한의과대학 심계내과학교실)
  • Published : 2002.06.30
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Abstract

Objectives : This study was designed to investigate the effects of Yukmijihwang-tang on contusion of the mice induced with medicine. Methods : I observed the effects of light and electron microscopes. and examined hematological changes and VEGF-immunohistochemistry. Results : Hematology: Leukocytes were increased significantly in a control group of mice compared with the experimental group. Light microscope : A few neurons were condensed in the 7-day experimental group, but condensed remarkedly in the 3-day control group. Most glial cells were observed in the 3-day experimental group. Edema and dilatation of vessels occurred significantly in the 3-day control group, and these results occurred weakly in the 7-day experimental group. VEGF-immunohistochemistry : VEGF-immunohistochemical reactivity for the glial cells was the highest in the 3-day experimental group, and immunoreactivity for the vessels and neurons highly increased in the 7-day experimental group. Electron microscope : In the 3-day control group, protoplasmic astrocytes concerned with angiogenesis contained weakly developed rough endoplasmic reticulum. and a few of glial filaments were observed. In the 7-day experimental group, the bundles of glial filaments were found in the cytoplasmic process of astrocytes. Conclusion : medication using Yukmijihwang-tang of mice contused by medical stress is highly effective in inflamatory response, curing cell damage and angiogenesis.

Keywords

References

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