대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
권호 표지

Multiple Infarction과 Small Artery Infarction의 독립적 위험인자로서의 Methylenetetrahydrofolate Reductase Gene Mutation

The Predictive Value of the Methylenetetrahydrofolate Reductase Gene Mutation for Multiple Infarction and Small Artery Infarction

  • 정정욱 (포천중문의과대학교 분당차한방병원 한의학교실 내과) ;
  • 박정미 (포천중문의과대학교 분당차한방병원 한의학교실 내과) ;
  • 최병옥 (포천중문의과대학교 분당차병원 신경과학교실) ;
  • 김남근 (포천중문의과대학교 분당차병원 임상의학연구소) ;
  • 오도연 (포천중문의과대학교 분당차병원 임상의학연구소) ;
  • 정우상 (포천중문의과대학교 분당차한방병원 한의학교실 내과)
  • Jung, Jung-Uk (Department of Internal Oriental Medicine, College of Medicine, Pochon Jung Moon University) ;
  • Park, Jung-Mi (Department of Internal Oriental Medicine, College of Medicine, Pochon Jung Moon University) ;
  • Choi, Byung-Ok (Department of Neurology, College of Medicine, Pochon Jung-Moon University) ;
  • Kim, Nam-Keun (Institute for Clinical Research, College of Medicine, Pochon Jung-Moon University) ;
  • Oh, Do-Yeun (Institute for Clinical Research, College of Medicine, Pochon Jung-Moon University) ;
  • Jung, Woo-Sang (Department of Internal Oriental Medicine, College of Medicine, Pochon Jung Moon University)
  • 발행 : 2002.03.30
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초록

Objective : Hyperhomocysteinemia has been proven to be an independent risk factor for stroke. The genetic mutation of methylenetetrahydrofolate reductase(MTHFR) elevates serum homocysteine level, but it still remains controversial whether the MTHFR gene mutation could be a predictor of ischemic stroke. Therefore, we studied if this genetic defect could cause ischemic stroke independently. Methods : We gathered ischemic stroke subjects and age, sex-matched controls. Age, gender, past medical history, smoking habit, serum homocysteine level, and the MTHFR genotype were recorded. General characteristics of ischemic stroke subjects were compared to the controls. We classified the stroke according to the related vessels(small and large artery infarction) and single lesion and multiple infraction. Relevant risk of the MTHFR genotype was evaluated in each stroke subtype with multiple logistic regression analysis. Results : When the controls were compared to the whole ischemic stroke, there was no specific difference except some medical histories. However, further analysis based on stroke subtypes showed important results. The small artery infarction group, multiple infraction group had significant odds ratio of the MTHFR TT genotype adjusted for age, gender, medical history and smoking habit. Conclusions : The MTHFR TT genotype is an independent risk factor for certain types of ischemic stroke, small artery infarction and multiple infarction.

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참고문헌

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