THE JOURNAL OF KOREAN ORIENTAL ONCOLOGY (대한한방종양학회지)

Korean Association of Traditional Oncology (대한암한의학회)
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Effect of Banhasasim-tang on the Hepatic and Splenic Toxicity induced by Doxorubicin

반하사심탕(半夏瀉心湯)이 Doxorubicin에 의해 유발(誘發)된 간장(肝臟) 및 비장(脾臟) 독성(毒性)에 미치는 영향(影響)

  • Hwang, Hui-Jeung (Dept. of Internal Medicine, College of Oriental Medicine, Kyungsan University) ;
  • Shin, Min-Kyu (Dept. of Internal Medicine, College of Oriental Medicine, Kyungsan University) ;
  • Kwak, Min-Ah (Dept. of Internal Medicine, College of Oriental Medicine, Kyungsan University) ;
  • Lee, Yun-Hee (Dept. of Internal Medicine, College of Oriental Medicine, Kyungsan University) ;
  • Kim, Sang-Chan (Dept. of Formulae Pharmacology, College of Oriental Medicine, Kyungsan University) ;
  • Byun, Joon-Seok (Dept. of Internal Medicine, College of Oriental Medicine, Kyungsan University)
  • 황희정 (경산대학교 한의과대학 내과학 교실) ;
  • 신민규 (경산대학교 한의과대학 내과학 교실) ;
  • 곽민아 (경산대학교 한의과대학 내과학 교실) ;
  • 이윤희 (경산대학교 한의과대학 내과학 교실) ;
  • 김상찬 (경산대학교 한의과대학 방제학 교실) ;
  • 변준석 (경산대학교 한의과대학 내과학 교실)
  • Published : 2002.12.30
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Abstract

Object The effect of Banhasasim-tang extracts on the hepatic, splenic toxicity and induced by Doxorubicin administration(Three injection protocol) were monitored using male ICR mice. Method The changes of body weigh, organ weights of liver and spleen were observed with blood GOT and GPT level. Results 1. Increase of absolute and relative liver weight observed in Doxorubicin treatment group were dose-dependently inhibited by Banhasasim-tang extracts. In addition, the degrees of liver congestion and necrotic spot were significantly and dose-dependently decreased after Banhasasim-tang extracts dosing groups compared to that of Doxorubicin treatment group. It is also demonstrated that elevated serum GOT and GPT levels in Doxorubicin treatment group were significantly decreased in Banhasasim-tang extracts dosing groups. 2. Decrease of absolute and relative spleen weight observed in Doxorubicin treatment group were dose dependently inhibited by Banhasasim-tang extracts. In addition, the degrees of splenic atrophy were significantly and dose-dependently decreased after Banhasasim-tang extracts dosing groups compared to that of Doxorubicin treatment group.

Keywords

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