Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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The effect of Codonopsis lanceolata on the melanogenesis

더덕추출물이 멜라닌생성에 미치는 영향

  • Lee Seung-Yon (Professional Graduate School of Oriental Medicine, Won Kwang University) ;
  • Kim Jin-Man (Professional Graduate School of Oriental Medicine, Won Kwang University) ;
  • Oh Hyun-Chul (Professional Graduate School of Oriental Medicine, Won Kwang University) ;
  • Im Sook-Jung (Professional Graduate School of Oriental Medicine, Won Kwang University) ;
  • Hwang Chung-Yeon (Professional Graduate School of Oriental Medicine, Won Kwang University) ;
  • Mun Yeun-Ja (Professional Graduate School of Oriental Medicine, Won Kwang University) ;
  • Woo Won-Hong (Professional Graduate School of Oriental Medicine, Won Kwang University)
  • 이승연 (원광대학교 한의학전문대학원) ;
  • 김진만 (원광대학교 한의학전문대학원) ;
  • 오현철 (원광대학교 한의학전문대학원) ;
  • 임숙정 (원광대학교 한의학전문대학원) ;
  • 황충연 (원광대학교 한의학전문대학원) ;
  • 문연자 (원광대학교 한의학전문대학원) ;
  • 우원홍 (원광대학교 한의학전문대학원)
  • Published : 2002.12.30
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Abstract

Acquired pigmentary skin diseases such as abnormal melanogenesis, vitiligo, chloasma and inflammatory pigmentation are related to regulate the melanin production. The aim of this study was to investigate the effect of Codonopsis lanceolata on the melanogenesis of HM3KO human melanoma cells biologically. The cells were treated for 5 days with Codonopsis lanceolata at several concentrations. Treatment with Codonopsis lanceolata suppressed melanin contents as a dose dependent manner without cytotoxicity and morphological change. And the extract of Codonopsis lanceolata also inhibited tyrosinase, a key enzyme forming melanin, in a dose-dependent manner. And it did not affect the DOPAchrome tautomerase(TRP-2) activity. These results suggest that Codonopsis lanceolata is a candidate for an efficient whitening agent which supresses melanogenesis by a Raper-Mason pathway.

Keywords

References

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