Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Effects of Daehwanggamchoeumja and its component groups on diabetes, free radical and antioxidative defense system in Alloxan-induced diabetic rats

대황감초음자(大黃甘草飮子)와 그 구성약물군(構成藥物群)이 Alloxan 유도 당뇨(糖尿) 백서(白鼠)의 혈청 조성 및 항산화 효과에 미치는 영향

  • Go Won-Do (Department of Oriental Medical Prescription Dongguk university) ;
  • Gwak Dong-Gul (Department of Oriental Medical Prescription Dongguk university) ;
  • Shin Hwa-Seog (Department of Oriental Medical Prescription Dongguk university) ;
  • Choi Oi-Chul (Department of Oriental Medical Prescription Dongguk university) ;
  • Park Sun-Dong (Department of Oriental Medical Prescription Dongguk university)
  • 고원도 (동국대학교 한의과대학 방제학교실) ;
  • 곽동걸 (동국대학교 한의과대학 방제학교실) ;
  • 신화석 (동국대학교 한의과대학 방제학교실) ;
  • 최오철 (동국대학교 한의과대학 방제학교실) ;
  • 박선동 (동국대학교 한의과대학 방제학교실)
  • Published : 2002.12.30
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Abstract

The purpose of this study was to reseach the effect of Daehwanggamchoeumja(大黃甘草飮子) and its component groups on diabetes, free radicals, and antioxidants system in Alloxan-induced diabetic rats. The experimental group was divided into three groups: Daehwanggamchoeumja(DG), and its components groups, Gamdutang (Gamcho&Daedu; DG-I) and Daehwanggamchotang(DG-2). The results were obtained as follows: 1. In the study of effect on diabetic metabolic dysfunction(Glucose, Triglyceride, Total Cholesterol, HDL Cholesterol, Total Protein, Albumin, Creatine, BUN), only DG has a significant effect. 2. In the study on free radical scavenging effect in vitro(the suppressing effect on peroxidation of linoleic acid on concentration, the scavenging effect of DPPH radical, inhibitory effect of superoxide in xanthine-xanthine oxidase system, inhibitory effect on lipid peroxidation reaction by hydroxy radical in $H_2O_2Fe^{2-}$system, and the effect on Nitrate reductase activity), DG and DG-2 have more effect than DG-l relatively. 3. In the study on antioxidants system in vivo(The level of serum LPO, The level of hepatic LPO, Catalase, GSH, GST), only DG has a significant effect. These results suggest that Daehwanggamchoeumja(大黃甘草飮子) has an effect on diabetes, peroxidative damage by free radical, so it seems to be useful to prevent and treat diabetes. The mechanisms of these are supposed to be involved in antioxidant and three drugs' cooperative synergy effect.

Keywords

References

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