Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
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BONE FORMATION BY HUMAN ALVEOLAR BONE CELLS

사람 치조골세포를 이용한 골형성

  • Choi, Byung-Ho (Dept. of Oral & Maxillofacial Surgery, College of Dentistry, Yonsei University) ;
  • Park, Jin-Hyoung (Dept. of Oral & Maxillofacial Surgery, College of Dentistry, Yonsei University) ;
  • Huh, Jin-Young (Dept. of Dentistry, Asan Kangnung Hospital) ;
  • Oh, Jin-Rok (Dept. of Orthopedics, Wonju College of Medicine, Yonsei University)
  • 최병호 (연세대학교 치과대학 구강악안면외과학교실(원주기독병원)) ;
  • 박진형 (연세대학교 치과대학 구강악안면외과학교실(원주기독병원)) ;
  • 허진영 (아산강릉병원 치과) ;
  • 오진록 (연세대학교 원주의과대학 정형외과학교실)
  • Published : 2002.02.28
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Abstract

Cultures of primary human alveolar bone-derived cells were established from alveolar bone chips obtained from normal individuals undergoing tooth extraction. These cells were expanded in vitro until passage 3 and used for the in vivo assays. Cells were loaded into transplantation vehicles, and transplanted subcutaneously into immunodeficient mice to study the capacities of human alveolar bone-derived cells to form bone in vivo. Transplants were harvested 12 weeks after transplantation and evaluated histologically. Of 10 human alveolar bone-derived cell transplants, two formed a bone-like tissue that featured osteocytes and mineral. Eight of the ten formed no osseous tissue. These results show that cells from normal human alveolar bone are capable of forming bone-like tissue when transplanted into immunodeficient mice.

Keywords

References

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