Journal of Pharmaceutical Investigation

  • 제32권4호
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  • Pages.305-311
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  • 2002
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  • 2093-5552(pISSN)
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  • 2093-6214(eISSN)
한국약제학회 (The Korean Society of Pharmaceutical Sciences and Technology)
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딜티아젬 함유 코아 펠렛으로부터 약물의 용출에 미치는 폴록사머 함량의 영향

Effect of Poloxamer Content on Dissolution of Diltiazem Hydrochloride from Core Pellets

  • 발행 : 2002.12.20
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초록

In order to evaluate the effect of poloxamer 407 content on the dissolution profiles of pellets, diltiazem HCl (DTL) core pellets were prepared with poloxamer 407 (50-90% w/w, with lactose as filler) using an extruder and a spheronizer. Any possible interaction between the drug and excipients was evaluated using DSC, IR and TLC. Dissolution tests were performed using USP basket method. In addition, scanning electron micrograph was performed to examine the surface roughness and cross sections. The release of DTL from the core pellets was decreased with increasing poloxamer 407 content. Cracks appeared on the surface of the core pellets with increasing the poloxamer 407 content, which may play a role on the retardation of the release of DTL from core pellets. There was no any significant interaction between the drug and excipients employed to prepare the core pellets.

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참고문헌

  1. C.M. Won and A.K. Iula, Kinetics of hydrolysis of diltiazem, Int. J. Pharm., 79, 183-190 (1992) https://doi.org/10.1016/0378-5173(92)90109-F
  2. K. Uekama, T. Horikawa, Y. Horiuchi and F. Hirayama, In vitro and in vivo evaluation of delayed-release behavior of diltiazem from its O-carboxymethyl-O-ethyl-$\beta$-cyclodextrin complex, J. Contr. Rel., 25, 99-106 (1993) https://doi.org/10.1016/0168-3659(93)90098-P
  3. K. Klokkers-Bethke and W. Fisher, Development of a multiple unit drug delivery system for positioned release in the gastrointestinal tract, J. Contr. Rel., 15, 105-112 (1991) https://doi.org/10.1016/0168-3659(91)90068-O
  4. G.K. McEvoy, Diltiazem hydrochloride in AHFS Drug Information, American Society of Health-System Pharma- cists, Wisconsin, 1317-1324 (1998)
  5. F. Carli, G. Capone, I. Colombo, L. Magarotto and A. Motta, Surface and transport properties of acrylic polymers influencing drug release from porous matrices, Int. J. Pharm., 21, 317-329 (1984) https://doi.org/10.1016/0378-5173(84)90190-X
  6. M. Lovrecich, F. Nobile, F. Rubessa and G. Zingone, Effect of ageing on the release of indomethacin from solid dispersion with Eudragits, Int. J. Pharm., 131, 247-255 (1996) https://doi.org/10.1016/0378-5173(95)04354-3
  7. W.L. Rocco, C. Morphet and S.M. Laughlin, Solid-state characterization of Zanoterone, Int. J. Pharm., 122, 17-25 (1995) https://doi.org/10.1016/0378-5173(95)00030-M
  8. O.I. Corrigan, E.M. Holohan and M.R. Reilly, Physico- chemical properties of indomethacin and related compounds co-spray dried with polyvinylpyrrolidone, Drug Dev. Ind. Pharm., 11, 677-695 (1985) https://doi.org/10.3109/03639048509056895
  9. K.P.R. Chowdary and K.V.V.S. Babu, Dissolution, bioavailability and ulcerogenic studies on solid dispersions of indomethacin in water soluble cellulose polymers, Drug Dev. Ind. Pharm., 20, 799-813 (1994) https://doi.org/10.3109/03639049409038332
  10. S. Eerikainen, Effect of spheronization on some properties of uncoated and coated granules containing different kinds of fillers, Int. J. Pharm., 77, 89-106 (1991) https://doi.org/10.1016/0378-5173(91)90307-A
  11. S. Eerikainen and A.S. Lindqvist, The behaviour of various fillers in spheronized uncoated and film-coated granules containing slightly water-soluble indomethacin, Int. J. Pharm., 75, 181-192 (1991) https://doi.org/10.1016/0378-5173(91)90192-Q
  12. K.E. Fielden, J.M. Newton and R.C. Rowe, The influence of lactose paricle size on spheronization of extrudate processed by a ram extruder, Int. J. Pharm., 81, 205-224 (1992) https://doi.org/10.1016/0378-5173(92)90013-R
  13. R. Bianchini, G. Bruni, A. Gazzaniga and C. Vecchio, Influence of extrusion-spheronization processing on the physical properties of d-indobufen pellets containing pH adjusters, Drug Dev. Ind. Pharm., 18, 1485-1503 (1992) https://doi.org/10.3109/03639049209040854
  14. S.L. Law, F.M. Lin and C.H. Chaing, Dissolution and absorption of nifedipine in polyethylne glycol solid dispersion containing phosphatidylcholine, Int. J. Pharm., 84, 161-166 (1992) https://doi.org/10.1016/0378-5173(92)90056-8