한국식품과학회지 (Korean Journal of Food Science and Technology)

한국식품과학회 (Korean Society of Food Science and Technology)
권호 표지

귀뚜라미의 수용성 및 알콜 추출물의 간보호 효과

Protective Effects of Water/Methanol Extracts of Cricket on the Acute Hepatic Damages in the ICR-mice Induced by Administration of $CCl_4$

  • 안미영 (농업과학기술원 잠사곤충부) ;
  • 이용우 (농업과학기술원 잠사곤충부) ;
  • 류강선 (농업과학기술원 잠사곤충부) ;
  • 이희삼 (농업과학기술원 잠사곤충부) ;
  • 김익수 (농업과학기술원 잠사곤충부) ;
  • 김진원 (농업과학기술원 잠사곤충부) ;
  • 이용기 (농업과학기술원 잠사곤충부) ;
  • 김은선 (농업과학기술원 잠사곤충부) ;
  • 김영식 (서울대학교 천연물과학연구소)
  • Ahn, Mi-Young (Department of Sericulture and Entomology, National Institute of Agricultural Science and Technology, RDA) ;
  • Lee, Yong-Woo (Department of Sericulture and Entomology, National Institute of Agricultural Science and Technology, RDA) ;
  • Ryu, Kang-Sun (Department of Sericulture and Entomology, National Institute of Agricultural Science and Technology, RDA) ;
  • Lee, Heui-Sam (Department of Sericulture and Entomology, National Institute of Agricultural Science and Technology, RDA) ;
  • Kim, Ik-Soo (Department of Sericulture and Entomology, National Institute of Agricultural Science and Technology, RDA) ;
  • Kim, Jin-Won (Department of Sericulture and Entomology, National Institute of Agricultural Science and Technology, RDA) ;
  • Lee, Yong-Ki (Department of Sericulture and Entomology, National Institute of Agricultural Science and Technology, RDA) ;
  • Kim, Eun-Sun (Department of Sericulture and Entomology, National Institute of Agricultural Science and Technology, RDA) ;
  • Kim, Yeong-Shik (Natural Products Research Institute, Seoul National University)
  • 발행 : 2002.08.01
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초록

귀뚜라미의 곤충산업의 발달로 대량체계화 사육된 귀뚜라미의 새로운 용도 개발의 일환으로 귀뚜라미의 간보호 효과를 조사하였다. 사염화탄소로 6주령의 ICR 응성 생쥐에 급성간염을 유발시킨 후 귀뚜라미 물 추출물(20 mg/kg) 및 메탄올 추출물(20 mg/kg)을 각각 투여하여 GOT, GPT, LDH 간혈청 효소 활성을 조사한 결과 귀뚜라미 메탄올 추출물은 대조구에 비해 GOT, GPT, LDH치가 74, 50, 101% 감소하였다. 지질과산화 억제정도는 귀뚜라미 물추출물 및 메탄올추출물이 정상군 대비 40%이상의 억제 효과를 나타내었다. 또한 강제수영법에 의한 귀뚜라미 추출물의 항피로 효과를 측정시 대조군에 비해 메탄올 200 mg/kg에서 현저한 수영시간 증가를 보여 양성대조군인 토코페롤 100 mg/kg 수준의 유의성 있는 항피로 효과를 나타낸 것을 알 수 있었다. 이상의 결과로 보아 귀뚜라미의 수용성 및 알콜추출물은 간보호 효과를 가지는 건강보조식품으로서 개발 가능성을 가짐을 알 수 있다.

Water and methanol extracts of cricket were examined for their liver protective effects against $CCl_4-intoxication$ in ICR-mice. Serum transaminases (S-GOT and S-GPT), lactate dehydrogense (LDH) and glutathione-S-transferase (GST) activities and TBARS (Thiobarbiturate-reactive substances) content were measured for evaluation of liver protective effects. The activities of GOT, GPT, LDH and hepatic content of lipid peroxide after $CCl_4-treatment$ were higher than normal control but those levels decreased th 74, 50, 101 and 40%, respectively, by the treatment of cricket methanol extract. The anti-fatigue effects of water and methanol extracts investigated by an acute weight-loaded forced swimming test showed significantly prolonged swimming time in the mice administered cricket extracts. These results suggest us that water/alcohol extract of G. bimaculatus may be used as a liver protective food.

키워드

참고문헌

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