한국식품과학회지 (Korean Journal of Food Science and Technology)

한국식품과학회 (Korean Society of Food Science and Technology)
권호 표지

가시오가피 열수추출물의 전신성 Anaphylaxis에 대한 억제효과

Effect of Hot Water Extract from Acanthopanax senticosus on Systemic Anaphylaxis

  • Yoon, Taek-Joon (Department of Food Science and Biotechnology, Kyonggi University) ;
  • Lee, Seok-Won (Department of Oncology, Graduate School of E-W Medical Science, KyungHee University) ;
  • Shin, Kwang-Soon (Department of Food Science and Biotechnology, Kyonggi University) ;
  • Choi, Won-Hee (Research & Development Team, GooFoo Inc) ;
  • Hwang, Soo-Hyun (Department of Food Science and Biotechnology, Kyonggi University) ;
  • Seo, Sang-Hee (Research & Development Team, GooFoo Inc) ;
  • Kim, Sung-Hoon (Department of Oncology, Graduate School of E-W Medical Science, KyungHee University) ;
  • Park, Woo-Mun (Research & Development Team, GooFoo Inc)
  • 발행 : 2002.06.01
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초록

마우스에서 가시오가피 열수추출물(GF-2)의 투여는 compound 48/80에 의하여 유도되는 전신성 anaphylactic shock 및 혈중 histamine과 호산구의 생산을 GF-2 농도 의존적으로 억제하였을 뿐 아니라, 마우스 복강세포에서 LPS에 의하여 유도되는 $TNF-{\alpha}$의 생산을 유의적으로 감소시켰다. 또한, 마우스에 항원으로서 ovalbumin(OVA)와 adjuvant로서 aluminium hydroxide를 사용하여 면역 후, OVA에 대한 IgG1 및 IgE 항체의 역가를 조사한 결과, GF-2의 투여는 이들 항체의 생산을 억제하였다. 이 결과는 GF-2를 항원 특이적 혹은 비특이적인 알러지 반응에 응용할 수 있는 소재로 개발 가능성 있음을 제시하였다.

Administration of hot water extracts from Acanthopanax senticosus (GF-2) prophylactically and therapeutically inhibited the systemic anaphylactic shock induced by compound 48/80 in mouse. GF-2 significantly inhibited the production of histamine and eosinophyl in mouse serum through the injection of compound 48/80 in a dose-dependent manner. GF-2 inhibited dose dependently $TNF-{\alpha}$ production of peritoneal exudative cells activated by lipopolysaccharide. Intraperitoneal injection of GF-2 suppressed the production of IgG1 and IgE antibodies in mice immunized with a mixture of ovalbumin and aluminium hydroxide. These results suggest that GF-2 may be beneficial for the treatment of nonspecific and specific anaphylactic reactions and can be potentially applied to the treatment of allergic diseases.

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