Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Antioxidant Effects of the Extracts of Acanthopanax senticosus

가시오갈피 추출물의 항산화효과

  • Jin, Li-Hua (Division of Biotechnology, Kangwon National University) ;
  • Han, Sang-Sup (Division of Forest Resources, Kangwon National University) ;
  • Choi, Yong-Soon (Division of Biotechnology, Kangwon National University)
  • 김려화 (강원대학교 생명공학부) ;
  • 한상섭 (강원대학교 산림자원학부) ;
  • 최용순 (강원대학교 생명공학부)
  • Published : 2002.12.30
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Abstract

Antioxidant properties of the extracts of Acanthopanax senticosus were investigated. The dried roots, stems or leaves were extracted with hot water or ethanol each. The ethanol extracts exhibited higher potency than aqueous extracts in scavenging free radicals and in inhibiting microsomal lipid peroxidation: the aqueous extracts of stems showed higher anti-oxidant effects than the root extracts. Copper-mediated LDL oxidation was also protected by the ethanol exlracts: antioxidant effects of the extracts tested were stronger than ascorbic acid, but not butylated hydroxytoluene. The activity of angiotensin converting enzyme was effectively suppressed by the aqueous extracts of the stems. However, in vivo antioxidant properties of the ethanol extracts of the stems did not seem to be significant, judged from the lipid peroxide values of serum and liver in normal mice. Thus, the ethanol extracts of the stems were shown to be more potent for protecting biological systems against various oxidant stresses in vitro, but not in vivo.

Keywords

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