Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Inhibitors of Melanogenesis from the Roots of Peucedanum praeruptorum

전호의 멜라닌 생성 억제 물질

  • 김원찬 (엘지생활건강 화장품 연구소) ;
  • 진무현 (엘지생활건강 화장품 연구소) ;
  • 김호정 (엘지생활건강 화장품 연구소) ;
  • 강상진 (엘지생활건강 화장품 연구소) ;
  • 강세훈 (엘지생활건강 화장품 연구소) ;
  • 정민환 (엘지화학 분석센타) ;
  • 임영희 (엘지화학 분석센타) ;
  • 김청택 (엘지생활건강 화장품 연구소)
  • Published : 2002.12.30
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Abstract

A chemical investigation of Peucedanum praeruptorum has resulted in the isolation of 3 khellactone derivatives, which have inhibitory effects on melanogenesis in Bl6 mouse melanoma cell lines. The khellactone derivatives were isolated from the crude extract of the roots of Pecedanum praeruptorum by a combination of adsorption chromatography and HPLC. The structlues of isolated compounds were identified as 3',4'- diangeloyl-cis-khellactone, 3'-angeloyl- 4'- senecioyl-cis-khel- lactone and,3', 4'-disenecioyl-cis-khellactone by $^1H\;NMR$, $^{13}C\;NMR$ and mass spectral studies and by comparisons of spectral data with reported literatures.

Keywords

References

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